Results 61 to 70 of about 1,878,239 (300)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Canada's National Parks: The Cutting Edge of Commercialization

The Canadian field-naturalist, 1972
(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
openaire   +1 more source

Characterization of Botrytis cinerea From Commercial Cut Flower Roses [PDF]

Plant Disease, 2019
Botrytis cinerea Pers. infects cut flower roses (Rosa × hybrida L.) during greenhouse production and gray mold symptoms are often expressed in the postharvest environment, resulting in significant economic losses. Disease management is based on cultural practices and preventative chemical treatments; however, gray mold outbreaks continue to occur ...
M. Muñoz, J. E. Faust, G. Schnabel
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

ASSESSING TEXTURE TO FIVE BEEF MEAT CUTS PRESERVED BY STERILIZATION IN TINPLATE PACKAGING

Vitae, 2009
In order to define consumer acceptance by texture analysis, the variables that affect quality of beef cuts for canning are analyzed by instrumental and sensory methods. Five beef cuts, commonly used by consumers, are selected, characterized and evaluated,
Luz M. CARVAJAL C., Nelly OSPINA M., Olga L. MARTÍNEZ A., Liliana RAMÍREZ S., Claudia C. RESTREPO, Sandra S. ADARVE E., Sara L. RESTREPO E.   +6 more
doaj  

Association of CYP2A6 gene related to the characteristic carcass, commercial cuts, quality of meat and cholesterol of lamb meat

Journal of the Indonesian Tropical Animal Agriculture
As meat-producing livestock, sheep are a benchmark for communities seeking quality and healthy meat. The CYP2A6 gene has emerged as a potential tool for improving lamb meat quality.
R. F. Istiqlal, K. Listyarini, J. Jakaria, C. Budiman, A. Gunawan   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Multiple linear regression to predict carcass tissue composition in hair lambs raised under commercial system

Revista Científica
The aim of the present study was to predict the carcass tissue composition of hair lambs reared on a commercial system, based on the characteristics of commercial cuts using multiple linear regression. In the study, thirty crossbred male lambs (Pelibuey
Rodrigo Portillo-Salgado, Juan Escobedo-Canul, Dany Alejandro Dzib-Cauich, Ángel Carmelo Sierra-Vásquez, Emilio Pérez-Pacheco, Víctor Manuel Moo-Huchin, Alfonso Juventino Chay-Canul, Raciel Javier Estrada-León   +7 more
doaj   +1 more source

A study on the temperature of cutting fluid in the micro-cutting of commercially pure titanium

Abstract The sustainable machining is a delicate issue because it does not depend only on the environment aspects. A simple solution would be to remove the use of cutting fluids, however, in the machining of difficult-to-cut materials, the use of cutting fluid can be strongly recommended.
João Octávio Marçal Assis, Carlos Henrique Lauro, Robson Bruno Dutra Pereira, Lincoln Cardoso Brandão, Étory Madrilles Arruda, João Paulo Davim   +5 more
openaire   +1 more source