Results 131 to 140 of about 191,559 (334)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Giant Aneurysm of Thoracic and Proximal Abdominal Aorta in a Patient with Common Variable Immunodeficiency

Iranian Journal of Allergy, Asthma and Immunology, 2011
Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency disease, predisposing the patients to various tissue involvement and organ damage.
Sara Kashef, Mozhgan Moghtaderi, Mohammad Borzouee, Nima Rezaei   +3 more
doaj  

Common variable immunodeficiency misdiagnosed as Crohn Disease [PDF]

, 2015

core   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Germline Mutations in NFKB2 Implicate the Noncanonical NF-κB Pathway in the Pathogenesis of Common Variable Immunodeficiency [PDF]

, 2013
Karin Chen, Emily Coonrod, Attila Kumánovics, Zechariah F. Franks, Jacob Durtschi, Rebecca L. Margraf, Wilfred Wu, Nahla Heikal, Nancy H. Augustine, Perry G. Ridge, Harry R. Hill, Lynn B. Jorde, Andrew S. Weyrich, Guy A. Zimmerman, Adi V. Gundlapalli, John F. Bohnsack, Karl V. Voelkerding   +16 more
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

"HUMAN LEUKOCYTE CLASS I AND II ANTIGENS IN IRANIAN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY" [PDF]

Acta Medica Iranica, 2004
Common variable immunodeficiency (CVID) is a heterogeneous heritable disease characterized by arrest in B cell differentiation. An association between CVID and two HLA haplotypes, haplotype I (HLA-A1, HLA-B8, HLA-DR3) and haplotype II (HLA-A29, HLA-B44 ...
"A. Aghamohammadi, A. Farhoudi, H. Hosseini Nik, Sh. Khazali, Z. Pourpak, F. Khosravi, A. Sarrafnezhad, AA. Amir-Zargar, N. Rezaei, K. Abolmaali, D. Mansouri B. Nikbin"   +10 more
doaj  

Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID) [PDF]

, 2007
Lilit Garibyan, Adrian A. Lobito, Richard M. Siegel, Matthew E. Call, Kai W. Wucherpfennig, Raif S. Geha   +5 more
openalex   +1 more source

The clinical observation of a patient with common variable immunodeficiency diagnosed as having coronavirus disease 2019 [PDF]

, 2020
Lauren Fill, Lauren Hadney, Kelsey Graven, Roberta Persaud, Robert Hostoffer   +4 more
openalex   +1 more source

The prevalence, clinical relevance and origin of autoantibodies in patients with Common variable immunodeficiency on regular immunoglobulin replacement therapy – the results from a prospective observational study [PDF]

, 2021
Tomáš Milota, Karel Kotaška, Petr Laštůvka, Jitka Smetanová, Markéta Bloomfield, Radana Zachová, Iveta Klojdová, Rudolf Horváth, Anna Šedivá   +8 more
openalex   +1 more source