Results 111 to 120 of about 111,659 (285)

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Genetics and clinical phenotypes in common variable immunodeficiency

Frontiers in Genetics
Common variable immunodeficiency (CVID) is one of the most common symptomatic groups of inborn errors of immunity. In addition to infections resulting from insufficient levels of immune globulins and antibodies, many patients develop inflammatory or ...
Charlotte Cunningham-Rundles, Charlotte Cunningham-Rundles, Charlotte Cunningham-Rundles, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Jean-Laurent Casanova, Bertrand Boisson, Bertrand Boisson, Bertrand Boisson   +10 more
doaj   +1 more source

Infections in 252 patients with common variable immunodeficiency.

, 2008
International audienceBACKGROUND: Common variable immunodeficiency is characterized by recurrent infections and defective immunoglobulin production.
Gael Mouillot, Felipe Suarez, Pauline Soulas‐Sprauel, Soulas-Sprauel, Pauline, Martine Gardembas, Jaccard, Arnaud, Patrice Debré, Lionel Galicier, Suarez, Felipe, Debré, Patrice, Ioannis Théodorou, Viallard, Jean-François, Eric Oksenhendler, Claire Fieschi, Nicolas Schleinitz, Mouillot, Gael, Laurence Gérard, Galicier, Lionel, Hachulla, Eric, Oksenhendler, Eric, Schleinitz, Nicolas, Arnaud Jaccard, Renseigné, Non, Jean‐François Viallard, Théodorou, Ioannis, Gardembas, Martine, Jaussaud, Roland, Rabian, Claire, Claire Rabian, Malphettes, Marion, null null, Fieschi, Claire, Gérard, Laurence, Gardeur, Anaelle, Marion Malphettes, Roland Jaussaud, Anaelle Gardeur, Eric Hachulla   +37 more
core   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Noncaseating Granulomatous Disease in Common Variable Immunodeficiency

, 2000
Patients with common variable immunodeficiency (CVID) are occasionally recognized to have a concurrent noncaseating granulomatous disease. The granulomatous disease (GD) associated with CVID shares many clinical properties typical of sarcoidosis.
Byrd, R P., Roy, T. M., Kanathur, N, Fields, C L.   +3 more
core  

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Current concepts: Common variable immunodeficiency

Annals of Allergy, Asthma & Immunology
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency disorder found in clinical medicine. The immune defect occurs in males and females equally and is characterized by reduced serum levels of IgG, deficient IgA and/or IgM levels, and poor to absent specific antibody responses to infection or vaccinations ...
openaire   +3 more sources

Autoimmune manifestations in common variable immunodeficiency

, 2004
Common variable immunodeficiency (CVID) is a disorder characterized by decreased serum immunoglobulin concentrations and increased incidence of recurrent infections.
Soliotis, F, Giannouli, S, Voulgarelis, M, Anagnostou, D   +3 more
core  

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source