Results 91 to 100 of about 111,659 (285)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Common variable immunodeficiency-associated heterozygous transcription factor 3 (TCF3) gene mutations in two pediatric cases

Common variable immunodeficiency (CVID) is one of the predominant antibody deficiencies and the most common symptomatic inborn error of immunity (IEI). However, in most cases, the genetic background of the disease cannot be identified.
Ümmügülsüm Dikici, Öner Özdemir, Murat Hakkı Yarar   +2 more
core   +1 more source

Encephalomyelitis with Retinopathy in Common Variable Immunodeficiency (CVID) [PDF]

, 2020
Common variable immunodeficiency is the most common primary immunodeficiency and rarely causes neurological manifestations since the introduction of IVIg, but here, the authors present a case of a 31-year-old Afro-Caribbean man who after short non ...
Nitkunan, A, Ali, N, Hayman, G, Bridges, L, Habibi, M, Katanga, J, Mackinnon, A, Shribman, S   +7 more
core  

Piecing together the subtle clues of common variable immunodeficiency

, 2023
Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder that results in decreased immunity and increased infection risk. This multisystem disorder often presents as recurrent, prolonged respiratory tract infections.
Kochanoff, Kimberly DeVore
core   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

A Late-Diagnosed Case of Common Variable Immunodeficiency

Ahi Evran Medical Journal
Common Variable Immunodeficiency (CVID) is the most common form of primary immunodeficiency (PID). CVID is characterized by decreased serum immunoglobulin levels, decreased or absent antibody production, and normal or low B-lymphocyte counts.
Coşkun Doğan, Nurhan Kasap, Cihan Örçen   +2 more
doaj   +1 more source

Pathogenesis of autoimmunity in common variable immunodeficiency (CVID)

Frontiers in Immunology, 2012
Common variable immunodeficiency (CVID) presents in up to 25% of patients with autoimmune (AI) manifestations. Given the frequency and early onset in patients with CVID, AI dysregulation seems to be an integral part of the immunodeficiency.
Klaus eWarnatz, Reinhard E Voll
doaj   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Migratory pneumonia caused by common variable immunodeficiency disorder

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Recurrent respiratory infections are important causes for bronchiectasis which can also be caused by a severe or poorly treated single infective event.
Maged Hassan
doaj   +1 more source