Results 101 to 110 of about 6,848,720 (280)

Lymphoma in common variable immunodeficiency: interplay between immune dysregulation, infection and genetics [PDF]

, 2008
PURPOSE OF REVIEW: Common variable immunodeficiency represents the largest group of primary immunodeficiency patients. The variable clinical manifestations include an increased susceptibility to chronic infections, granulomatous disease and the ...
Bodo Grimbacher, Ignatius Chua, QUINTI, Isabella   +2 more
core   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Common Variable Immunodeficiency (CVI) 1례

, 1987
Common variable immunodeficiency is a heterogeneous group of disorders characterized by hypogammaglobulinemia, impaired antibody response and recurrent bacterial infections. Although it is represented by an acquired defect of humoral immunity, cellular
Ahn, Hyo Sup, Cho, Myung Chul, Park, Myoung Hee, Chi, Je G., Park, Byung Kiu, Moon, Hyung Ro, Lee, Hoan Jong   +6 more
core  

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Migratory pneumonia caused by common variable immunodeficiency disorder

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Recurrent respiratory infections are important causes for bronchiectasis which can also be caused by a severe or poorly treated single infective event.
Maged Hassan
doaj   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source

Common variable immunodeficiency-associated heterozygous transcription factor 3 (TCF3) gene mutations in two pediatric cases

Common variable immunodeficiency (CVID) is one of the predominant antibody deficiencies and the most common symptomatic inborn error of immunity (IEI). However, in most cases, the genetic background of the disease cannot be identified.
Ümmügülsüm Dikici, Öner Özdemir, Murat Hakkı Yarar   +2 more
core   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Infections in 252 patients with common variable immunodeficiency. [PDF]

, 2008
International audienceBACKGROUND: Common variable immunodeficiency is characterized by recurrent infections and defective immunoglobulin production.
Gael Mouillot, Felipe Suarez, Pauline Soulas‐Sprauel, Soulas-Sprauel, Pauline, Martine Gardembas, Jaccard, Arnaud, Patrice Debré, Lionel Galicier, Suarez, Felipe, Debré, Patrice, Ioannis Théodorou, Viallard, Jean-François, Eric Oksenhendler, Claire Fieschi, Nicolas Schleinitz, Mouillot, Gael, Laurence Gérard, Galicier, Lionel, Hachulla, Eric, Oksenhendler, Eric, Schleinitz, Nicolas, Arnaud Jaccard, Renseigné, Non, Jean‐François Viallard, Théodorou, Ioannis, Gardembas, Martine, Jaussaud, Roland, Rabian, Claire, Claire Rabian, Malphettes, Marion, null null, Fieschi, Claire, Gérard, Laurence, Gardeur, Anaelle, Marion Malphettes, Roland Jaussaud, Anaelle Gardeur, Eric Hachulla   +37 more
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source