Results 71 to 80 of about 6,848,720 (280)

CVID-associated TACI mutations affect autoreactive B cell selection and activation [PDF]

, 2013
Common variable immune deficiency (CVID) is an assorted group of primary diseases that clinically manifest with antibody deficiency, infection susceptibility, and autoimmunity.
Tuure Kinnunen, Gentile, M, Cantaert, T, Tineke Cantaert, Menard, L, Laurence Menard, Morbach, H, Saadoun, D, Virdee, M, Neil Romberg, Kinnunen, T, Maurizio Gentile, Rachid, R, Martinez-Pomar, N, Geha, R, Henner Morbach, Matamoros, N, Cunningham-Rundles, C, Nicolas Chamberlain, Nuria Matamoros, Andrea Cerutti, Yen Shing Ng, Bodo Grimbacher, Natalia Martinez-Pomar, Meffre, E, Eric Meffre, David Saadoun, Manmeet Virdee, Rima Rachid, Cerutti, A, Raif Geha, Romberg, N, Brimbacher, B, Chamberlain, N, Charlotte Cunningham-Rundles, Ng, YS   +35 more
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Absence of chronic hepatitis E in a German cohort of common variable immunodeficiency patients

Infectious Disease Reports, 2012
Cases of chronic or prolonged hepatitis E virus (HEV) infections have been described in solid organ transplant recipients, HIV infected patients and in patients with malignancies or idiopathic CD4+ T lymphopenia. It is unknown if HEV infection also takes
Sven Pischke, Ruediger Horn-Wichmann, Diana Ernst, Bjoern Georg Meyer, Regina Raupach, Gerrit Ahrenstorf, Reinhold Ernst Schmidt, Michael Peter Manns, Torsten Witte, Heiner Wedemeyer   +9 more
doaj   +1 more source

Birdshot-like chorioretinopathy in common variable immunodeficiency

, 2012
CASE REPORT BIRDSHOT-LIKE CHORIORETINOPATHY IN COMMON VARIABLE IMMUNODEFICIENCY de Maeyer, Véronique MD*; Leroy, Bart P. MD, PhD*,†; Kerre, Tessa MD, PhD‡; Ferdinande, Liesbeth MD§; Haerynck, Filomeen MD¶; De Baets, Frans MD, PhD¶; Kestelyn, Philippe MD,
Kerre, Tessa, Ferdinande, Liesbeth, Haerynck, Filomeen, de Maeyer, Véronique, Kestelyn, Philippe, Leroy, Bart, De Baets, Frans   +6 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Functions of Tfh Cells in Common Variable Immunodeficiency

Frontiers in Immunology, 2020
Common variable immunodeficiency is the most common clinical primary immunodeficiency in adults. Its hallmarks are hypogammaglobulinemia and compromised B-cell differentiation into memory or antibody-secreting cells leading to recurrent infections.
Corentin Le Saos-Patrinos, Séverine Loizon, Patrick Blanco, Patrick Blanco, Jean-François Viallard, Dorothée Duluc   +5 more
doaj   +1 more source

Management of a patient with common variable immunodeficiency and hepatopathy

Allergy, Asthma & Clinical Immunology, 2023
Background Common variable Immunodeficiency (CVID) is a primary immunodeficiency disorder and the most common form of severe antibody deficiency. Both children and adults are affected and clinical manifestations vary widely.
Lea Grümme, Hendrik Schulze-Koops
doaj   +1 more source

NEUROENDOCRINE TUMOR IN A CHILD WITH COMMON VARIABLE IMMUNODEFICIENCY

, 2020
Objective: To report a case of a child with primary immunodeficiency who at eight years developed digestive symptoms, culminating with the diagnosis of a neuroendocrine tumor at ten years of age.
Maria Conceição Santos de Menezes (8047160), Heloísa Gabriel Tersariol (8047154), Wilma Carvalho Neves Forte (4648414), Pedro de Souza Lucarelli Antunes (8047151), Mainã Marques Belém Veiga (8047157), Fabíola Del Carlo Bernardi (8047163)   +5 more
core   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source