Results 151 to 160 of about 111,659 (285)

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

Animal Models and Experimental Medicine, EarlyView.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li, Ziqing Jia, Zhe Cong, Jianrong Ma, Jiahan Lu, Yongzhi Hou, Fei Wang, Jiasen Yang, Ting Chen, Jingjing Zhang, Dong Zhang, Jing Xue   +11 more
wiley   +1 more source

Multiniche mycobiome profiling identifies distinctive fungal dysbiosis in common variable immunodeficiency. [PDF]

Front Immunol
Cabanero-Navalon MD, Carda-Diéguez M, Mira A, Moral Moral P, Diaz Luna MM, Balastegui-Martín H, Salavert Lletí M, Garcia-Bustos V.   +7 more
europepmc   +1 more source

Common Variable Immunodeficiency with Hypoglycemia, Kikuchi Lymphadenitis , and Hemiparesis in Two Siblings

, 2008
Common variable immunodeficiency is a heterogeneous group of disorders with arthritis and/or arthralgia as its most commonly associated autoimmune manifestation. We report 2 cases of common variable immunodeficiency in siblings who also had other unusual
HWU, WUH-LIANG;CHIANG, BOR-LUEN, 胡務亮;江伯倫   +1 more
core  

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Beyond the Usual Suspects: Gastrointestinal Histoplasmosis as a Marker of Undiagnosed Common Variable Immunodeficiency. [PDF]

ACG Case Rep J
Pacheco Oliva J, Meléndez Rodríguez N, Sánchez A, López Chacón JL.   +3 more
europepmc   +1 more source

Differences in SARS‐CoV‐2 Antigen Persistence in Individuals With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A RECOVER‐Adult Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post–acute COVID‐19 outcomes, though whether individuals with SARDs have longer persistence of viral antigens after COVID‐19 has not been studied.
Naomi J. Patel, Zoe Swank, Jiaqi Wang, Xiaosong Wang, Lauren A. O'Keeffe, Madison Negron, Liya S. Getachew, Louise L. Hansen, Grace Qian, Alene A. Saavedra, Kevin T. Mueller, Natalie A. Davis, Kathleen M. M. Vanni, Sandria Savage, Julie S. Lam, Zachary S. Wallace, David R. Walt, Jeffrey A. Sparks, on behalf of RECOVER‐Adult   +18 more
wiley   +1 more source

Common Variable Immunodeficiency and Peripheral Lung Nodule

Clinical Medicine Insights: Case Reports, 2008
Miguel Ángel Núñez, Javier Velasco, Jose Luis Hernandez M.D., Ph.D., Cristina Castrillo, Maria Luisa Cagigal   +4 more
doaj   +1 more source

CXCL13 as a Biomarker of Complex Common Variable Immunodeficiency. [PDF]

J Clin Immunol
Karafotias I, Martini H, Lee CV, Hunter TTJ, Gurugama P, Guckian M, Steven R, Jolles S, Peakman M, Fear D, Ibrahim MAA.   +10 more
europepmc   +1 more source

Clinicaland laboratory features of a case of common variable immunodeficiency

, 2012
Загальна варіабельна імунна недостатність (ЗВІН) є одним із найбільш розповсюджених первинних імунодефіцитів та характеризується порушенням продукції сироваткових імуноглобулінів IgG, IgM, IgA, а також специфічних антитіл.
Прилуцкий, А.С., Прилуцкая, И.С., Ткаченко, К.Е., Присташ, Н.И.   +3 more
core