Results 161 to 170 of about 6,848,720 (280)

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Chronic spontaneous urticaria as an autoimmune feature in common variable immunodeficiency. [PDF]

J Allergy Clin Immunol Glob
Korevaar ECA, Karim AF, Dalm VASH.
europepmc   +1 more source

Pharmacokinetic profiling of imatinib in relation to CYP3A4 activity in leukaemia patients

British Journal of Clinical Pharmacology, EarlyView.
Aim Imatinib pharmacokinetics exhibit large interindividual variability because of differences in CYP3A4 activity—the main imatinib‐metabolizing enzyme. While therapeutic drug monitoring is effective, it requires steady‐state conditions and frequent sampling.
Anna Sofie Buhl Rasmussen, Mathilde Rønne Koch, Cecilie Utke Rank, Christen Lykkegaard Andersen, Allan Weimann, Maria Thastrup, Tianwu Yang, Trine Meldgaard Lund, Ib Jarle Christensen, Flemming Nielsen, Tore Bjerregaard Stage, Sara Bisgaard Jensen, Mette Klarskov Andersen, Kjeld Schmiegelow, Kim Dalhoff   +14 more
wiley   +1 more source

Pseudomonal sternal abscess and osteomyelitis as an initial manifestation of common variable immunodeficiency. [PDF]

ASM Case Rep
Makram M, Bou Sanayeh E, Itani H, Moussa E, Zayed A, Glaser A.   +5 more
europepmc   +1 more source

From Undifferentiated Connective Tissue Disease to Common Variable Immunodeficiency: A Novel NFKB1 Mutation in a Pediatric Case. [PDF]

Clin Case Rep
Hu YJ, Hao S, Feng D, Huang BX, Huang WY.   +4 more
europepmc   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

Altered duodenal N6-methyladenosine levels in common variable immunodeficiency associate with duodenal microbiota. [PDF]

Front Immunol
Myhre V, Kaarbø M, Yang M, Fevang B, Sousa MML, Reims HM, Lundin KEA, Hov JR, Aukrust P, Bjørås M, Jørgensen SF.   +10 more
europepmc   +1 more source

Clinicaland laboratory features of a case of common variable immunodeficiency

, 2012
Загальна варіабельна імунна недостатність (ЗВІН) є одним із найбільш розповсюджених первинних імунодефіцитів та характеризується порушенням продукції сироваткових імуноглобулінів IgG, IgM, IgA, а також специфічних антитіл.
Прилуцкий, А.С., Прилуцкая, И.С., Ткаченко, К.Е., Присташ, Н.И.   +3 more
core  

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb–Drug Interaction Investigation

Biopharmaceutics &Drug Disposition, EarlyView.
Pharmacokinetic interactions between Echinacea and two antiviral drugs, favipiravir and atazanavir, were assessed in rats. The findings suggest that Echinacea does not significantly affect the pharmacokinetics of favipiravir and atazanavir. These results provide preliminary evidence that concurrent use of Echinacea with these antiviral drugs may be ...
Siva Nageswara Rao Gajula, Jeevan Sai Kallam, Aarika Kanukolanu, Ganesh Korada, Lakshmi Vineela Nalla   +4 more
wiley   +1 more source

Acute portal vein thrombosis postimage-guided liver biopsy in common variable immunodeficiency. [PDF]

Radiol Case Rep
Morar SK, Morar KN.
europepmc   +1 more source