Results 191 to 200 of about 109,095 (245)

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

The Burden of Non-Infectious Organ-Specific Immunopathology in Pediatric Common Variable Immunodeficiency. [PDF]

Int J Mol Sci
Szczawińska-Popłonyk A, Bekalarska J, Jęch K, Knobloch N, Łukasik O, Ossowska A, Ruducha J, Wysocka Z.   +7 more
europepmc   +1 more source

Expansion of CD57⁺ CD8 T cells in common variable immunodeficiency with hepatopathy and CMV infection. [PDF]

Front Immunol
Bez P, Santangeli E, Goldacker S, Salzer U, Warnatz K.   +4 more
europepmc   +1 more source

Respiratory profile of pediatric patients undergoing hematopoietic stem cell transplantation studied by oscillometry – A TRANSPIRE cohort

Pediatric Investigation, EarlyView.
These are results from a multi‐center collaboration between four large pediatric institutions, investigating baseline respiratory system function in a cohort of children undergoing hematopoietic stem cell transplantation. This manuscript proposes respiratory oscillometry as a novel way to prospectively follow lung function in these children.
Maureen B. Parenti, Julian Allen, Lisa R. Young, Heather Boas, Jason Freedman, Christopher Towe, Jane Koo, Kasiani Myers, Jason C. Woods, Adam Lane, Jonathan Gaffin, Wai Wong, Leslie Lehmann, Fernando Urrego, Gabriel Salinas Cisneros, Matthew F. Abts, K. Scott Baker, Manuel Silva‐Carmona, Erin Doherty, Paul D. Robinson, Margaret MacMillan, Stella M. Davies, Samuel B. Goldfarb   +22 more
wiley   +1 more source

Paucity of gastrointestinal plasma cells in common variable immunodeficiency. [PDF]

Curr Opin Allergy Clin Immunol
Marsden JWN, Laclé MM, Severs M, Leavis HL.   +3 more
europepmc   +1 more source

Early Cervical and Orofacial Variable Dystonia in Levodopa‐Naïve PRKN Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Amy Gallagher, Aine Redmond, John McKinley, John Inocentes, Diana A Olszewska, Conor Fearon, Tim Lynch   +6 more
wiley   +1 more source

Advances in Viral Markers for Predicting Functional Cure of Chronic Hepatitis B

Portal Hypertension &Cirrhosis, EarlyView.
Functional cure, defined as sustained hepatitis B surface antigen (HBsAg) loss, is achieved by only a minority of patients with chronic hepatitis B (CHB); early identification of likely responders may improve cure rates and reduce costs. However, responses to antiviral therapy vary considerably, necessitating reliable hepatitis B virus (HBV) viral ...
Xinrong Lu, Xin Yang, Qishui Ou, Zhen Xun   +3 more
wiley   +1 more source

Common variable immunodeficiency: autoimmune cytopenias and advances in molecular diagnosis. [PDF]

Hematology Am Soc Hematol Educ Program
Cunningham-Rundles C, Casanova JL, Boisson B.   +2 more
europepmc   +1 more source

RNA‐binding protein RBMS1: A new target for cancer diagnosis and treatment

Precision Medical Sciences, EarlyView.
This schematic illustrates the diverse regulatory roles of RNA‐binding motif single‐stranded interacting protein 1 (RBMS1) across multiple human cancers. In breast cancer, RBMS1 stabilizes B4GALT1 mRNA to promote PD‐L1 glycosylation, modulating tumor immune escape and immunotherapy efficacy.
Xingda Run, Shiwei Jiang, Kun Xu, Yu Fan, Yanwen Chen, Ziao Liu, Zengli Miao, Wei Tian   +7 more
wiley   +1 more source

Real-world patterns of immunoglobulin replacement therapy for infection prevention in common variable immunodeficiency: a multicenter nationwide study. [PDF]

Front Immunol
Moral Moral P, Garcia-Bustos V, Balastegui-Martin H, Martínez Mercader S, Bracke C, Mateu L, Solanich X, Antolí A, Carrillo-Linares JL, Robles-Marhuenda Á, Puchades F, Pelaez Ballesta A, López-Osle N, Torralba-Cabeza MÁ, Bielsa Masdeu AM, Gil Niño J, Tornador Gaya N, Pascual Castellanos G, Sánchez-Martínez R, Barragán-Casas JM, González-García A, Patier de la Peña JL, López-Wolf D, Mora Rufete A, Canovas Mora A, Cabañero-Navalon MD.   +25 more
europepmc   +1 more source