Results 41 to 50 of about 189,403 (288)

Common variable immunodeficiency in a patient with Noonan syndrome

Alergologia Polska
Noonan syndrome is a disease that occurs in 1 in 1,000–2,500 live births, mostly inherited in an autosomal dominant manner. Noonan syndrome is a clinically and genetically heterogeneous disease that may be accompanied by growth retardation, prominent ...
Öner Özdemir, Ümmügülsüm Dikici, Ece Tüsüz Önata, Recep Polat   +3 more
doaj   +1 more source

Common Variable Immunodeficiency: molecular pathways and clinical manifestations [PDF]

, 2012
Common variable immunodeficiency (CVID), is a disease that is characterized by hypogammaglobulinemia as well as a defect in T, B and dendritic cells.
Leuthold, E.
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Common variable immunodeficiency associated enteropathy: a diagnostic enigma in developing countries

Journal of the Pakistan Medical Association
Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency disorder with different phenotypes and aetiologies. It is characterised by hypogammaglobulinaemia, defects in specific antibody response, erroneous activation and ...
Muhammad Aftab Hassan, Muhammad Hussain, Dawood Ahmad, Muhammad Omair Riaz, Muhammad Zain Arshad   +4 more
doaj   +1 more source

A “strange” case of COPD

Clinical Management Issues, 2015
Common variable immunodeficiency (CVID) is a rare syndrome, characterized by hypogammaglobulinemia and limited antibody responses due to either impaired B-lymphocyte development or B-cell responses to T-lymphocyte signals.
Laura Massarelli, Valerio Tomaselli, Carlo Bussolino, Valter Saracco   +3 more
doaj   +1 more source

Retinoic acid induces the differentiation of B cell hybridomas from patients with common variable immunodeficiency. [PDF]

, 1988
Human-human B cell hybridomas constructed from B lymphocytes of common variable immunodeficiency (CVI) patients and the nonsecreting cell line WIL2/729 HF consistently secrete low levels of Ig and appear to retain a defect characteristic of the CVI ...
Adelman, DC, Gilly, M, Saxon, A, Sherr, E, Sidell, N, Wall, R   +5 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Multimorbid Patient with Primary Immunodeficiency. Diagnostics, Treatment

Архивъ внутренней медицины
Primary immunodeficiency is a pathological condition of immune system, expressed in the absence or decrease certain parts of immune system. It was generally believed that primary immunodeficiency is a rare pathology but recent findings indicate the ...
V. N. Larina, E. V. Kudina, T. A. Matvejchuk, E. N. Sheregova, O. O. Vinokurova   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Educational Case: AA Amyloidosis Complicating Common Variable Immunodeficiency

Academic Pathology, 2021
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology.
Meghan E. Kapp MD, MS, Mark A. Lusco MD, Aaron C. Shaver MD, PhD   +2 more
doaj   +1 more source