Results 51 to 60 of about 191,559 (334)

Multimorbid Patient with Primary Immunodeficiency. Diagnostics, Treatment

Архивъ внутренней медицины
Primary immunodeficiency is a pathological condition of immune system, expressed in the absence or decrease certain parts of immune system. It was generally believed that primary immunodeficiency is a rare pathology but recent findings indicate the ...
V. N. Larina, E. V. Kudina, T. A. Matvejchuk, E. N. Sheregova, O. O. Vinokurova   +4 more
doaj   +1 more source

Common Variable Immunodeficiency: molecular pathways and clinical manifestations [PDF]

, 2012
Common variable immunodeficiency (CVID), is a disease that is characterized by hypogammaglobulinemia as well as a defect in T, B and dendritic cells.
Leuthold, E.
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

AB1468 ENTEROPATHY IN DUTCH COMMON VARIABLE IMMUNODEFICIENCY COHORT [PDF]

, 2023
Norsham Juliana, Mirjam Severs, Jacques van Montfrans, Pauline M. Ellerbroek, Bas Oldenburg, J. Van Roon, Helen L. Leavis   +6 more
openalex   +1 more source

Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders. [PDF]

, 2014
In the present study, we have investigated the functional profile of CD4 T cells from patients with common variable immunodeficiency (CVID), including production of cytokines and proliferation in response to bacteria and virus-derived antigens.
Anthony, Aukrust, Barber, Bayry, Bloom, Bonhomme, Brandtzaeg, Brenchley, Brenchley, Butcher, Castigli, Cellerai, Champagne, Christine Lacabaratz, Coruh, Cunningham-Rundles, Cunningham-Rundles, Cunningham-Rundles, Céline Pellaton, David, Day, De Gast, Deeks, Denis Comte, Florence Bellanger, Giovannetti, Giuseppe Pantaleo, Grimbacher, Guillaume Buss, Haney, Hong, Ishihara, Ito, Kuijpers, Levy, Lieberman, Matthieu Perreau, McHeyzer-Williams, McMahan, Morita, Morris, Nathan, Orange, Paquin-Proulx, Paquin-Proulx, Park, Parker, Perreau, Perreau, Petrovas, Pierre-Alexandre Bart, Raeiszadeh, Reinherz, Roederer, Roger, Sallusto, Selena Vigano, Sneller, Thierry Roger, Trautmann, Van der Hilst, van Zelm, van Zelm, Wehr, Yamamoto, Ye, Yves Levy   +66 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Educational Case: AA Amyloidosis Complicating Common Variable Immunodeficiency

Academic Pathology, 2021
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology.
Meghan E. Kapp MD, MS, Mark A. Lusco MD, Aaron C. Shaver MD, PhD   +2 more
doaj   +1 more source

Evaluation of MicroRNA-125b-5p and Transcription Factors BLIMP1 and IRF4 Expression in Unsolved Common Variable Immunodeficiency Patients

Iranian Journal of Allergy, Asthma and Immunology, 2021
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary humoral immunodeficiencies characterized by failure in the final differentiation of B lymphocytes. The majority of CVID cases have no identified genetic defect, and
Zahra Hamidi Esfahani, Reza Yazdani, Sepideh Shahkarami, Fateme Babaha, Hassan Abolhassani, Maryam Sadr, Ali Akbar Pourfathollah, Asghar Aghamohammadi   +7 more
doaj   +1 more source

An investigation of the breadth of neutralising antibody response in cats naturally infected with feline immunodeficiency virus [PDF]

, 2015
Neutralising antibodies (NAbs) are believed to comprise an essential component of the protective immune response induced by vaccines against FIV and HIV infections.
Beczkowski, Pawel, Hosie, Margaret J., Litster, Annette, Logan, Nicola, McMonagle, Elizabeth, Willett, Brian J.   +5 more
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source