Results 61 to 70 of about 56,406 (298)

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Organoid models: applications and research advances in colorectal cancer

Frontiers in Oncology
This review summarizes the applications and research progress of organoid models in colorectal cancer research. First, the high incidence and mortality rates of colorectal cancer are introduced, emphasizing the importance of organoids as a research model.
Yijie Wu, Yijie Wu, Yu Sha, Xingpo Guo, Ling Gao, Jian Huang, Song-Bai Liu, Song-Bai Liu   +7 more
doaj   +1 more source

A Systematic Database Approach to Identify Companion Diagnostic Testing in Clinical Trials under the New In Vitro Diagnostic Medical Devices Regulation

Diagnostics, 2023
The European Union In Vitro Diagnostic Medical Devices Regulation (EU) 2017/746 (IVDR) introduces companion diagnostics (CDx) as a new legal term. CDx are applied in combination with a medicinal product to identify patient subgroups most likely to ...
Clara Wollenhaupt, Thomas Sudhop, Werner Knoess   +2 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

ZC3H12D gene expression exhibits dual effects on the development and progression of lung adenocarcinoma

Scientific Reports
While precision oncology requires robust biomarkers, current predictors for lung adenocarcinoma (LUAD) often show limited clinical utility. This study investigates the multifaceted roles of ZC3H12D, a novel immunomodulatory molecule, in LUAD progression ...
Yuansi Zheng, Yuhuan Zhang, Jieyi Li, Ying Su   +3 more
doaj   +1 more source

A Companion Diagnostic With Significant Clinical Impact in Treatment of Breast and Gastric Cancer

Frontiers in Oncology, 2021
The development of trastuzumab (Herceptin®) was one of the most significant cancer drug development projects of the 20th century. Not only was it a scientific and medical achievement but it also paved the way for the drug-diagnostic codevelopment model ...
Jan Trøst Jørgensen, Henrik Winther, Jon Askaa, Lena Andresen, Dana Olsen, Jens Mollerup   +5 more
doaj   +1 more source

Chandra HETGS Multi-Phase Spectroscopy of the Young Magnetic O Star theta^1 Orionis C

, 2005
We report on four Chandra grating observations of the oblique magnetic rotator theta^1 Ori C (O5.5 V) covering a wide range of viewing angles with respect to the star's 1060 G dipole magnetic field. We employ line-width and centroid analyses to study the
Asif ud‐Doula, Babel J., David H. Cohen, Feldmeier A., Feldmeier A., Gabriel A. H., Hillier D. J., Joseph J. MacFarlane, MacDonald J., Marc Gagne, Mary E. Oksala, Reiners A., Richard H. D. Townsend, Stahl O., Stahl O., Stanley P. Owocki, Stephanie K. Tonnesen, Weigelt G., Yamauchi S.   +18 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Molecular characterization and prognostic implications of KRAS mutations in pancreatic cancer patients: insights from multi-cohort analysis

npj Precision Oncology
KRAS mutations drive pancreatic adenocarcinoma (PDAC) progression. This study investigates molecular heterogeneity among KRAS subtypes and their prognostic implications.
Yubo Jiang, Gang Mai, Xiaokai Zhao, Meng Tang, Pengmin Yang, Qian Cheng, He Tian, Zuoxing Niu, Xintao Wang, Jiao Wang, Yudong Zhu, Jieyi Li, Ziying Gong, Daoyun Zhang, Huirong Xu   +14 more
doaj   +1 more source

The Labyrinth of Product Development and Regulatory Approvals in Liquid Biopsy Diagnostics

Clinical and Translational Science, 2019
The evolution of chemistries and instrument platforms for next‐generation sequencing has led to sequencing of genomic variants in both tumor biopsies as well as in circulating tumor cells (CTCs) and cell‐free DNA liquid biopsies.
Federico M. Goodsaid
doaj   +1 more source