Results 41 to 50 of about 56,406 (298)

Molecular tools for companion diagnostics

New Biotechnology, 2012
The heterogeneous nature of cancer results in highly variable therapeutic responses even among patients with identical stages and grades of a malignancy. The move towards personalised medicine in cancer therapy has therefore been motivated by a need to customise therapy according to molecular features of individual tumours. Companion diagnostics serves
Zieba A, Grannas K, Söderberg O, Gullberg M, Nilsson M, Landegren U   +5 more
openaire   +5 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Spatially-Resolved Spectroscopy of SDSS J0952+2552: a Confirmed Dual AGN [PDF]

, 2011
Most massive galaxies contain supermassive black holes (SMBHs) in their cores. When galaxies merge, gas is driven to nuclear regions and can accrete onto the central black hole. Thus one expects to see dual AGN in a fraction of galaxy mergers. Candidates
Ballo, Bonning, Civano, Comerford, Comerford, Decarli, Fischer, Fu, Gerke, Green, Guedes, Hennawi, Hennawi, Hopkins, Junkkarinen, Komossa, Koss, Liu, Liu, Liu, Lotz, Myers, Myers, Peng, Piconcelli, Richstone, Rodriguez, Rodríguez-Ardila, Rosario, Rosario, Smith, Spergel, Wang, Xu, Yu, Zhou   +35 more
core   +2 more sources

Dexamethasone for Chemotherapy‐Induced Nausea and Vomiting Prevention in Pediatric Patients: International Consensus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi, Paula D. Robinson, Shana Jacobs, L. Lee Dupuis, the International Pediatric Dexamethasone Panel, Sameer Bakhshi, Tiene Bauters, Eva Brack, Simone Cesaro, Claire Fosbrook, Jason Freedman, Tamara MacDonald, Eloise Neumann, Venkatraman Radhakrishnan, Rod Rassekh, Florian Slimano, Johnathan Soggee, Joel Thompson, Marianne van de Wetering, Milena Villarroel, Jasper Wong   +20 more
wiley   +1 more source

PD-L2 Expression in Breast Cancer Promotes Tumor Development and Progression

Journal of Immunology Research
Background. This work focused on investigating the role of programmed death ligand 2 (PD-L2) in the progression of breast cancer by utilizing breast cancer specimens and cells. Materials and Methods.
Yuling Sun, Jie Yang, Yachun Chen, Yundi Guo, Jian Xiong, Xuqin Guo, Yawen Zhang, Li Gu, Min Tong, Weipeng Wang, Jing Sun   +10 more
doaj   +1 more source

Decoding the molecular landscape: HER2 and PD-L1 in advanced gastric cancer

Frontiers in Immunology
IntroductionEpidermal growth factor receptor 2 (HER2) and programmed cell death ligand 1 (PD-L1) are pivotal therapeutic targets for advanced gastric cancer (GC).
Jun Yao, Qiang Sun, Han Wu, Xiaokai Zhao, Pengmin Yang, Xiaozhi Wang, Xintao Wang, Meiping Gu, Jieyi Li, Yuansi Zheng, Ziying Gong, Daoyun Zhang, Weijun Wang   +12 more
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations

Respiratory Research
Background Although EGFR-TKI resistance mechanisms in non-small cell lung cancer (NSCLC) have been extensively studied, certain patient subgroups remain with unclear mechanisms.
Wuwu Ding, Pengmin Yang, Xiaokai Zhao, Xiaozhi Wang, Huaqing Liu, Qing Su, Xintao Wang, Jieyi Li, Ziying Gong, Daoyun Zhang, Xinwei Wang   +10 more
doaj   +1 more source

Identification of an Extended Accretion Disk Corona in the Hercules X-1 Low State: Moderate Optical Depth, Precise Density Determination, and Verification of CNO Abundances

, 2004
We identify an accretion disk atmosphere and corona from the high resolution X-ray spectrum of Hercules X-1, and we determine its detailed physical properties.
Boroson B., C. J. Hailey, D. A. Liedahl, dal Fiume D., Grevesse N., J. C. Raymond, Kaastra J. S., Kaastra J. S., Klapisch M., M. A. Jimenez‐Garate, Mewe R., Reynolds A. P., Schaller G.   +12 more
core   +2 more sources

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source