Results 51 to 60 of about 56,406 (298)

Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay

Diagnostic Pathology, 2018
Background Several anti-programmed cell death-1 (PD-1) and anti-programmed cell death ligand-1 (PD-L1) therapies have shown encouraging safety and clinical activity in a variety of tumor types.
Paul Scorer, Marietta Scott, Nicola Lawson, Marianne J. Ratcliffe, Craig Barker, Marlon C. Rebelatto, Jill Walker   +6 more
doaj   +1 more source

Twenty-five years with companion diagnostics

Chinese Clinical Oncology, 2023
For decades, pharmacotherapy has been hampered by significant patient variability, and the inability to predict outcomes at the individual patient level has negatively affected its value. However, progress in molecular medicine has led to an increased understanding of the pathophysiology and mechanisms of action of drugs, thereby enabling the ...
openaire   +2 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

SDH mutations, as potential predictor of chemotherapy prognosis in small cell lung cancer patients

Discover Oncology, 2023
Purpose Small cell lung cancer (SCLC) is an aggressive and rapidly progressive malignant tumor characterized by a poor prognosis. Chemotherapy remains the primary treatment in clinical practice; however, reliable biomarkers for predicting chemotherapy ...
Ran Zeng, Xiaoyun Fan, Jin Yang, Chen Fang, Jieyi Li, Wei Wen, Jing Liu, Mengchen Lv, Xiangran Feng, XiaoKai Zhao, Hongjie Yu, Yuhuan Zhang, Xianwen Sun, Zhiyao Bao, Jun Zhou, Lei Ni, Xiaofei Wang, Qijian Cheng, Beili Gao, Ziying Gong, Daoyun Zhang, Yuchao Dong, Yi Xiang   +22 more
doaj   +1 more source

Beyond Circulating Tumor Cell Enumeration: Cell-Based Liquid Biopsy to Assess Protein Biomarkers and Cancer Genomics Using the RareCyte® Platform

Frontiers in Pharmacology, 2022
The practice of medicine has steadily employed less invasive methods to obtain information derived from the tumor to guide clinical management of patients. Liquid biopsy—the sampling of blood—is a non-invasive method for generating information previously
Eric P. Kaldjian, Arturo B. Ramirez, Lillian Costandy, Nolan G. Ericson, Walla I. Malkawi, Thaddeus C. George, Pashtoon Murtaza Kasi   +6 more
doaj   +1 more source

Collisional Plasma Models with APEC/APED: Emission Line Diagnostics of Hydrogen-like and Helium-like Ions

, 2001
New X-ray observatories (Chandra and XMM-Newton) are providing a wealth of high-resolution X-ray spectra in which hydrogen- and helium-like ions are usually strong features.
Drake G. W., Duane A. Liedahl, Ericsson G. W., John C. Raymond, Kisielius R., Klapisch M., Landini M., Nancy S. Brickhouse, Randall K. Smith, Vainstein L. A., Verner D. A.   +10 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Disk Evolution in Young Binaries: from Observations to Theory [PDF]

, 2006
The formation of a binary system surrounded by disks is the most common outcome of stellar formation. Hence studying and understanding the formation and the evolution of binary systems and associated disks is a cornerstone of star formation science ...
Clarke, C. J., McCabe, C., Monin, J. -L., Prato, L.   +3 more
core   +1 more source

Precise radial velocities of giant stars. III. Spectroscopic stellar parameters

, 2007
Context: A radial velocity survey of about 380 G and K giant stars is ongoing at Lick observatory. For each star we have a high signal to noise ratio template spectrum, which we use to determine spectroscopic stellar parameters.
Allende Prieto, Asplund, Bard, Benz, Blackwell, Butler, Castelli, Cayrel de Strobel, da Silva, de Medeiros, Fekel, Fischer, Fischer, Frink, Frink, Gonzalez, Gray, Hekker, J. Meléndez, Johnson, Luck, Marcy, May, Meléndez, Meléndez, Milford, Mishenina, O'Brian, Ramírez, Reffert, Robinson, S. Hekker, Sadakane, Santos, Santos, Santos, Sato, Schuler, Sousa, Sousa, Takeda, Takeda, Taylor, Tinker, Twarog, Valenti, Valenti   +46 more
core   +1 more source

Quantitative analysis of WC stars: Constraints on neon abundances from ISO/SWS spectroscopy [PDF]

, 2000
Neon abundances are derived in four Galactic WC stars -- gamma Vel (WR11, WC8+O7.5III), HD156385 (WR90, WC7), HD192103 (WR135, WC8), and WR146 (WC5+O8) - using mid-infrared fine structure lines obtained with ISO/SWS.
A. J. Willis, Abbott D. C., Barlow M. J., Becker S. R., Becker S. R., Becker S. R., Butler K., Cardelli J. A., Chapman J., Crowther P. A., Crowther P. A., Crowther P. A., D. John Hillier, de Graauw TH., de Jager C., De Marco O., Dougherty S. M., Dougherty S. M., Eenens P. R. J., Eenens P. R. J., Fernley J. A., Galavis M. E., Hillier D. J., Hillier D. J., Hillier D. J., Hillier D. J., Hillier D. J., Howarth I. D., Howarth I. D., Howarth I. D., K. A. van der Hucht, Kessler M., Koesterke L., L. Dessart, Langer N., Leitherer C., Lepine S., Lundstrom I., Luo D., Luo D., Massey P., Meynet G., Moffat A. F. J., Morris P. W., Morris P. W., Morris P. W., Niemela V., Nussbaumer H., Nussbaumer H., P. A. Crowther, P. W. Morris, Peach G., Prinja R. K., Saraph H. E., Saraph H. E., Schaerer D., Schaerer D., Schaller G., Schmutz W., Schmutz W., Seaton M. J., Smith L. F., St Louis N., Steenman H., Steenman H., Stevens I. R., Torres-Dodgen A. V., Torres-Dodgen A. V., Tully J. A., van der Hucht K. A., van der Hucht K. A., van der Hucht K. A., van der Hucht K. A., Willis A. J., Willis A. J., Wright A. E., Yu Yan, Yu Yan   +77 more
core   +2 more sources