Results 71 to 80 of about 175,797 (297)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Genomic profiling of rectal adenoma and carcinoma by array-based comparative genomic hybridization

BMC Medical Genomics, 2012
Background Rectal cancer is one of the most common cancers in the world. Early detection and early therapy are important for the control of death caused by rectal cancer. The present study aims to investigate the genomic alterations in rectal adenoma and
Shi Zhi-Zhou, Zhang Yue-Ming, Shang Li, Hao Jia-Jie, Zhang Tong-Tong, Wang Bo-Shi, Liang Jian-Wei, Chen Xi, Zhang Ying, Wang Gui-Qi, Wang Ming-Rong, Zhang Yu   +11 more
doaj   +1 more source

Intra- and Interspecies Analyses of the Carcinoembryonic Antigen (CEA) Gene Family Reveal Independent Evolution in Primates and Rodents [PDF]

, 1989
Various rodent and primate DNAs exhibit a stronger intra- than interspecies cross-hybridization with probes derived from the N-terminal domain exons of human and rat carcinoembryonic antigen (CEA)-like genes.
Rudert, Fritz, Thompson, John A., Zimmermann, Wolfgang   +2 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Gene duplication in an African cichlid adaptive radiation [PDF]

, 2014
Background Gene duplication is a source of evolutionary innovation and can contribute to the divergence of lineages; however, the relative importance of this process remains to be determined.
Joyce, Domino A, Joyce, Domino A., Jui, Ginger, Lunt, David H., Machado, Heather E, Machado, Heather E., Reilly, Christian R. L., Reilly, Christian R.L., Reilly, Christian RL, Renn, Suzy C. P., Renn, Suzy C.P., Renn, Suzy Cp, Renn, Suzy CP   +12 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]

, 2003
Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S., Edwards, J., Krishnan, S., Witton, C.J.   +3 more
core  

A Revised Design for Microarray Experiments to Account for Experimental Noise and Uncertainty of Probe Response [PDF]

, 2013
Background Although microarrays are analysis tools in biomedical research, they are known to yield noisy output that usually requires experimental confirmation.
A Halperin, A Halperin, A Harrison, A Held, A Pozhitkov, AE Pozhitkov, AE Pozhitkov, Alex E. Pozhitkov, AM Osborn, BE Lang, C Burden, CJ Burden, D Hekstra, D Steger, Diethard Tautz, FF Millenaar, FW Studier, GA Held, H Freundlich, H Yang, J Bryk, J Seo, J Shendure, Jarosław Bryk, JB Fan, Lars Kaderali, N Ono, OV Matveeva, Peter A. Noble, S Li, T Czypionka, T Heim, U Mueckstein, Y Barash   +33 more
core   +5 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Microbial genomic taxonomy [PDF]

, 2013
A need for a genomic species definition is emerging from several independent studies worldwide. In this commentary paper, we discuss recent studies on the genomic taxonomy of diverse microbial groups and a unified species definition based on genomics ...
Chimetto, Luciane, Edwards, Robert A, Stackebrandt, Erko, Swings, Jean, Thompson, Cristiane C, Thompson, Fabiano L   +5 more
core   +3 more sources