Results 81 to 90 of about 88,145 (306)

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

arrayCGHbase: an analysis platform for comparative genomic hybridization microarrays

BMC Bioinformatics, 2005
Background The availability of the human genome sequence as well as the large number of physically accessible oligonucleotides, cDNA, and BAC clones across the entire genome has triggered and accelerated the use of several platforms for analysis of DNA ...
Moreau Yves, Vermeesch Joris, van Vooren Steven, De Paepe Anne, Mortier Geert, Buysse Karen, Michels Evi, Robbrecht Piet, De Preter Katleen, Pattyn Filip, Menten Björn, De Moor Bart, Vermeulen Stefan, Speleman Frank, Vandesompele Jo   +14 more
doaj   +1 more source

Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes [PDF]

, 2011
Although the major food-borne pathogen Campylobacter jejuni has been isolated from diverse animal, human and environmental sources, our knowledge of genomic diversity in C.
French, Nigel P., Hinds, Jason, Hall, N, Hepworth, Philip J., Gould, Katherine A., Gould, Katherine A, Adam A. Witney, Ashelford, Kevin E., Birtles, Richard J, Philip J. Hepworth, Kevin E. Ashelford, Nicola J. Williams, Winstanley, Craig, Howard Leatherbarrow, Wren, BW, Witney, AA, Birtles, Richard J., Neil Hall, French, Nigel P, Katherine A. Gould, Witney, Adam A., Hinds, J, Williams, Nicola J., Jason Hinds, Nigel P. French, Winstanley, C, Leatherbarrow, Howard, Paul Wigley, Williams, Nicola J, Birtles, RJ, Wren, Brendan W, Craig Winstanley, Mendonca, C, Mendonca, Chriselle, Hepworth, Philip J, Gould, KA, Wigley, Paul, Brendan W. Wren, Wren, Brendan W., Nick Dorrell, French, NP, Wigley, P, Hepworth, PJ, Leatherbarrow, H, Williams, NJ, Witney, Adam A, Dorrell, Nick, Chriselle Mendonca, Hall, Neil, Dorrell, N, Ashelford, KE, Ashelford, Kevin E, Richard J. Birtles   +52 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Chromosomal Aberrations in Squamous Cell Carcinoma and Solar Keratoses Revealed by Comparative Genomic Hybridization

, 2003
Objective To identify chromosomal copy numbers of frequent genetic aberrations within squamous cell carcinomas (SCCs) and solar keratoses (SKs), and provide further evidence to support or challenge current dogma concerning the relationship between these
David J. Maguire, Weinstein, Stephen, Maguire, David, Lyn R. Griffiths, Griffiths, Lyn R., Kevin J. Ashton, Ashton, Kevin J., Griffiths, Lyn, Ashton, Kevin, Stephen R. Weinstein, Maguire, David J., Weinstein, Stephen R.   +11 more
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Cross-species overgo hybridization and comparative physical mapping within avian genomes

, 2006
The chicken genome sequence facilitates comparative genomics within other avian species. We performed cross-species hybridizations using overgo probes designed from chicken genomic and zebra finch expressed sequence tags (ESTs) to turkey and zebra finch ...
M. N. Romanov, Dodgson, Jerry B, Romanov, Michael N, J. B. Dodgson   +3 more
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Medical Implementation of Microarray Technology

Korean Journal of Clinical Laboratory Science, 2020
Microarray technology represents a critical new advance in molecular cytogenetics. The de-velopment of this approach has provided fundamental insights into the molecular pathogenesis in clinical cytogenetics and has provided a clue to many unidentified ...
Ji Un Kang
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source