Results 1 to 10 of about 2,755,876 (359)

The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human health

BMC Genomics, 2023
Comparative genomics is the comparison of genetic information within and across organisms to understand the evolution, structure, and function of genes, proteins, and non-coding regions (Sivashankari and Shanmughavel, Bioinformation 1:376-8, 2007 ...
Kristin Bornstein, Gary Gryan, E. S. Chang, Aron Marchler-Bauer, Valerie A. Schneider   +4 more
semanticscholar   +1 more source

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis

Nature Microbiology, 2022
Mycobacterium tuberculosis (Mtb) infection is notoriously difficult to treat. Treatment efficacy is limited by Mtb’s intrinsic drug resistance, as well as its ability to evolve acquired resistance to all antituberculars in clinical use.
Shuqi Li, Nicholas C. Poulton, Jesse Chang, Zachary A. Azadian, M. DeJesus, N. Ruecker, M. Zimmerman, Kathryn Eckartt, B. Bosch, Curtis A. Engelhart, Daniel F Sullivan, M. Gengenbacher, V. Dartois, D. Schnappinger, Jeremy M. Rock   +14 more
semanticscholar   +1 more source

EDGAR3.0: comparative genomics and phylogenomics on a scalable infrastructure

Nucleic Acids Res., 2021
The EDGAR platform, a web server providing databases of precomputed orthology data for thousands of microbial genomes, is one of the most established tools in the field of comparative genomics and phylogenomics.
M. Dieckmann, Sebastian Beyvers, Rudel Christian Nkouamedjo-Fankep, Patrick Hanel, L. Jelonek, J. Blom, A. Goesmann   +6 more
semanticscholar   +1 more source

Functional identification of two novel carbohydrate-binding modules of glucuronoxylanase CrXyl30 and their contribution to the lignocellulose saccharification

Biotechnology for Biofuels and Bioproducts, 2023
Background Glycoside hydrolase (GH) family 30 xylanases are a distinct group of xylanases, most of which have a highly specific catalytic activity for glucuronoxylan.
Jiawen Liu, Jingrong Zhu, Qian Xu, Rui Shi, Cong Liu, Di Sun, Weijie Liu   +6 more
doaj   +1 more source

Comparative Genomics of Peroxisome Biogenesis Proteins: Making Sense of the PEX Proteins

Frontiers in Cell and Developmental Biology, 2021
PEX genes encode proteins involved in peroxisome biogenesis and proliferation. Using a comparative genomics approach, we clarify the evolutionary relationships between the 37 known PEX proteins in a representative set of eukaryotes, including all common ...
Renate L. M. Jansen, Carlos Santana-Molina, Marco van den Noort, D. Devos, I. J. van der Klei   +4 more
semanticscholar   +1 more source

cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors

Nature Communications, 2022
Nucleotide second messengers, such as cAMP and c-di-GMP, regulate many physiological processes in bacteria, including biofilm formation. Here, the authors provide evidence of cross-talk between cAMP and c-di-GMP pathways through direct interaction of ...
Cong Liu, Di Sun, Jiawen Liu, Ying Chen, Xuge Zhou, Yunrui Ru, Jingrong Zhu, Weijie Liu   +7 more
doaj   +1 more source

Observations on chromosome-specific sequencing for the construction of cross-species chromosome homology maps and its resolution of human:alpaca homology

Molecular Cytogenetics, 2022
Background The history of comparative chromosome mapping is briefly reviewed, with discussion about the problem that occurs in chromosome painting when size heteromorphisms between homologues cause contamination in chromosomes sorted by flow cytometry ...
Malcolm A. Ferguson-Smith, Jorge C. Pereira, Ana Borges, Fumio Kasai   +3 more
doaj   +1 more source

Recent advances and perspectives in efforts to reduce the production and application cost of microbial flocculants

Bioresources and Bioprocessing, 2021
Microbial flocculants are macromolecular substances produced by microorganisms. Due to its non-toxic, harmless, and biodegradable advantages, microbial flocculants have been widely used in various industrial fields, such as wastewater treatment ...
Cong Liu, Di Sun, Jiawen Liu, Jingrong Zhu, Weijie Liu   +4 more
doaj   +1 more source

Dense sampling of bird diversity increases power of comparative genomics

Nature, 2020
Whole-genome sequencing projects are increasingly populating the tree of life and characterizing biodiversity1–4. Sparse taxon sampling has previously been proposed to confound phylogenetic inference5, and captures only a fraction of the genomic ...
Shaohong Feng, Josefin Stiller, Yuan Deng, J. Armstrong, Qi Fang, A. H. Reeve, Duo Xie, Guangji Chen, Chunxue Guo, B. Faircloth, Bent Petersen, Zongji Wang, Qi Zhou, M. Diekhans, Wanjun Chen, S. Andreu-Sánchez, A. Margaryan, Jason T. Howard, Carole Parent, George Pacheco, Mikkel-Holger S. Sinding, Lara Puetz, Emily L. Cavill, Ângela M. Ribeiro, L. Eckhart, J. Fjeldså, P. Hosner, R. T. Brumfield, L. Christidis, M. Bertelsen, Thomas Sicheritz-Pontén, D. Tietze, B. Robertson, G. Song, G. Borgia, S. Claramunt, I. Lovette, S. Cowen, P. Njoroge, J. Dumbacher, O. Ryder, J. Fuchs, M. Bunce, D. Burt, J. Cracraft, Guanliang Meng, S. Hackett, P. Ryan, K. Jønsson, I. Jamieson, R. D. da Fonseca, E. Braun, P. Houde, S. Mirarab, Alexander Suh, B. Hansson, Suvi Ponnikas, Hanna Sigeman, Martin Stervander, P. Frandsen, H. van der Zwan, R. van der Sluis, C. Visser, C. N. Balakrishnan, A. Clark, J. Fitzpatrick, R. Bowman, Nancy Chen, Alison Cloutier, Timothy B Sackton, S. Edwards, Dustin J. Foote, Subir B. Shakya, F. Sheldon, A. Vignal, André E. R. Soares, B. Shapiro, J. González‐Solís, Joan Ferrer-Obiol, J. Rozas, M. Riutort, Anna Tigano, V. Friesen, L. Dalén, Araxi O. Urrutia, T. Székely, Yang Liu, M. G. Campana, A. Corvelo, R. Fleischer, Kim M Rutherford, N. Gemmell, N. Dussex, H. Mouritsen, N. Thiele, K. Delmore, M. Liedvogel, A. Franke, M. Hoeppner, O. Krone, Adam M. Fudickar, B. Milá, E. Ketterson, A. Fidler, Guillermo Friis, Á. M. Parody-Merino, P. Battley, M. Cox, N. C. Lima, F. Prosdocimi, T. Parchman, B. Schlinger, Bette A. Loiselle, J. Blake, H. C. Lim, L. Day, Matthew J. Fuxjager, Maude W. Baldwin, M. Braun, Morgan E. Wirthlin, Rebecca B. Dikow, T. Ryder, G. Camenisch, L. Keller, Jeffrey M. DaCosta, M. Hauber, Matthew I. M. Louder, C. Witt, J. McGuire, J. Mudge, Libby C. Megna, Matthew D. Carling, Biao Wang, Scott A. Taylor, Glaucia Del-Rio, A. Aleixo, A. T. Vasconcelos, C. Mello, J. Weir, D. Haussler, Qiye Li, Huanming Yang, Jian Wang, F. Lei, C. Rahbek, M. Gilbert, G. Graves, E. Jarvis, B. Paten, Guojie Zhang   +149 more
semanticscholar   +1 more source

Carbohydrate-binding modules targeting branched polysaccharides: overcoming side-chain recalcitrance in a non-catalytic approach

Bioresources and Bioprocessing, 2021
Extensive decoration of backbones is a major factor resulting in resistance of enzymatic conversion in hemicellulose and other branched polysaccharides. Employing debranching enzymes is the main strategy to overcome this kind of recalcitrance at present.
Jiawen Liu, Di Sun, Jingrong Zhu, Cong Liu, Weijie Liu   +4 more
doaj   +1 more source