Results 41 to 50 of about 821,290 (231)
Summary of compensatory mutations.
, 2013 aType refers to the two types of first mutations. I indicates the first mutations, which increase the MFE of ancestral HSR; II indicates the first mutations, which decrease the MFE of ancestral HSR (see text for details).bECO (EFE) refers to the pair of ...
Yinwen Zhang (464111) +5 more
core +1 more source
Purging deleterious mutations under self fertilization: paradoxical recovery in fitness with increasing mutation rate in Caenorhabditis elegans. [PDF]
PLoS ONE, 2010 The accumulation of deleterious mutations can drastically reduce population mean fitness. Self-fertilization is thought to be an effective means of purging deleterious mutations. However, widespread linkage disequilibrium generated and maintained by self-
Levi T Morran +2 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss. [PDF]
PLoS Pathogens, 2009 Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) results from mutations in the viral protease (PR) that reduce PI binding but also decrease viral replicative capacity (RC).
Elisabeth Dam +9 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Empirical approaches to detecting the action of natural selection in Drosophila [PDF]
, 2004 This dissertation examines two aspects of how natural selection shapes the amount and pattern of genetic variation within and between species: (1) the role of positively selected alleles in shaping the variation within and between subpopulations of a ...
Baines, John
core +1 more source
Distribution of the number of compensatory mutations in HSR.
, 2013 In more than 30% of the first-mutated HSR with compensatory mutations, two or more compensatory mutations were detected.
Yinwen Zhang (464111) +5 more
core +1 more source
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding
BMC Evolutionary Biology, 2003 Background The rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories.
Adami Christoph +2 more
doaj +1 more source