Results 21 to 30 of about 821,290 (231)

Compensatory effects of M. tuberculosis rpoB mutations outside the rifampicin resistance-determining region

Emerging Microbes and Infections, 2021
Mycobacterium tuberculosis has been observed to develop resistance to the frontline anti-tuberculosis drug rifampicin, primarily through mutations in the rifampicin resistance-determining region (RRDR) of rpoB.
Pengjiao Ma, Tao Luo, Liang Ge, Zonghai Chen, Xinyan Wang, Rongchuan Zhao, Wei Liao, Lang Bao   +7 more
doaj   +1 more source

Compensatory evolution of pbp mutations restores the fitness cost imposed by β-lactam resistance in Streptococcus pneumoniae. [PDF]

PLoS Pathogens, 2011
The prevalence of antibiotic resistance genes in pathogenic bacteria is a major challenge to treating many infectious diseases. The spread of these genes is driven by the strong selection imposed by the use of antibacterial drugs. However, in the absence
Andrea G Albarracín Orio, Germán E Piñas, Paulo R Cortes, Melina B Cian, José Echenique   +4 more
doaj   +1 more source

Evolution of Mycobacterium tuberculosis drug resistance in the genomic era

Frontiers in Cellular and Infection Microbiology, 2022
Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice.
Camus Nimmo, James Millard, Valwynne Faulkner, Johana Monteserin, Hannah Pugh, Eachan Oliver Johnson   +5 more
doaj   +1 more source

Genomic Characterization of Drug-Resistant Mycobacterium tuberculosis L2/Beijing Isolates from Astana, Kazakhstan

Antibiotics, 2023
Kazakhstan ranks among the countries with the highest number of MDR-TB patients per 100,000 population worldwide. The successful transmission of local MDR strains of Mycobacterium tuberculosis (Mtb) poses a significant threat to disease control.
Dana Auganova, Sabina Atavliyeva, Asylulan Amirgazin, Akmaral Akisheva, Anna Tsepke, Pavel Tarlykov   +5 more
doaj   +1 more source

Analysis of the Fitness Effect of Compensatory Mutations [PDF]

, 2008
We extend our previous work on the ï¬tness effect of the ï¬xation of deleterious mutations on a population by incorporating the effect of compensatory mutations.
Liqing Zhang, Layne T. Watson, Zhang, Liqing, Watson, Layne T.   +3 more
core   +2 more sources

Pervasive cryptic epistasis in molecular evolution. [PDF]

PLoS Genetics, 2010
The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous.
Mark Lunzer, G Brian Golding, Antony M Dean   +2 more
doaj   +1 more source

Molecular Dynamics and MM-PBSA Analysis of the SARS-CoV-2 Gamma Variant in Complex with the hACE-2 Receptor

Molecules, 2022
The SARS-CoV-2 virus, since its appearance in 2019, has caused millions of cases and deaths. To date, there is no effective treatment or a vaccine that is fully protective.
Maurizio Cavani, Walter Arnaldo Riofrío, Marcelino Arciniega   +2 more
doaj   +1 more source

Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

eLife, 2019
Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of ...
Anett Dunai, Réka Spohn, Zoltán Farkas, Viktória Lázár, Ádám Györkei, Gábor Apjok, Gábor Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó, László Bodai, Balázs Papp, Csaba Pál   +12 more
doaj   +1 more source

Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains

mBio, 2022
Collateral sensitivity and resistance occur when resistance development toward one antimicrobial either potentiates or deteriorates the effect of others.
Vidar Sørum, Emma L. Øynes, Anna S. Møller, Klaus Harms, Ørjan Samuelsen, Nicole L. Podnecky, Pål J. Johnsen   +6 more
doaj   +1 more source

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag. [PDF]

PLoS ONE, 2013
Expression of HLA-B*57 and the closely related HLA-B*58:01 are associated with prolonged survival after HIV-1 infection. However, large differences in disease course are observed among HLA-B*57/58:01 patients.
Esther F Gijsbers, K Anton Feenstra, Ad C van Nuenen, Marjon Navis, Jaap Heringa, Hanneke Schuitemaker, Neeltje A Kootstra   +6 more
doaj   +1 more source