Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities [PDF]
FEMS Microbiology Ecology, 2023 Plasmids drive bacterial evolutionary innovation by transferring ecologically important functions between lineages, but acquiring a plasmid often comes at a fitness cost to the host cell.
Catriona Thompson +2 more
exaly +6 more sources
CopomuS—Ranking Compensatory Mutations to Guide RNA-RNA Interaction Verification Experiments [PDF]
International Journal of Molecular Sciences, 2020 In silico RNA-RNA interaction prediction is widely applied to identify putative interaction partners and to assess interaction details in base pair resolution.
Fabio Gutmann +2 more
exaly +3 more sources
The role of compensatory mutations in the emergence of drug resistance.
PLoS Computational Biology, 2006 Pathogens that evolve resistance to drugs usually have reduced fitness. However, mutations that largely compensate for this reduction in fitness often arise. We investigate how these compensatory mutations affect population-wide resistance emergence as a
Andreas Handel +2 more
doaj +2 more sources
Infection and Drug Resistance, 2018 Mallika Lavania,1 Itu Singh,1 Ravindra P Turankar,1 Anuj Kumar Gupta,2 Madhvi Ahuja,1 Vinay Pathak,1 Utpal Sengupta1 1Stanley Browne Laboratory, The Leprosy Mission Trust India, TLM Community Hospital Nand Nagari, 2Agilent Technologies India Pvt Ltd ...
Lavania M +6 more
doaj +1 more source
Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds [PDF]
Molecular Systems Biology, 2015 Since deleterious mutations may be rescued by secondary mutations during evolution, compensatory evolution could identify genetic solutions leading to therapeutic targets.
Marie Filteau +5 more
doaj +2 more sources
Reversion is most likely under high mutation supply when compensatory mutations do not fully restore fitness costs [PDF]
G3: Genes, Genomes, Genetics, 2022 Pleuni Pennings +2 more
exaly +2 more sources
Limits to Compensatory Mutations: Insights from Temperature-Sensitive Alleles [PDF]
Molecular Biology and Evolution, 2019 Tal Pupko +2 more
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Fast computational mutation-response scanning of proteins [PDF]
PeerJ, 2021 Studying the effect of perturbations on protein structure is a basic approach in protein research. Important problems, such as predicting pathological mutations and understanding patterns of structural evolution, have been addressed by computational ...
Julian Echave
doaj +2 more sources
Multi‐drug resistance and compensatory mutations in Mycobacterium tuberculosis in Vietnam [PDF]
Tropical Medicine and International HealthQuang Huy Nguyen
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Multidrug-resistant bacteria compensate for the epistasis between resistances. [PDF]
PLoS Biology, 2017 Mutations conferring resistance to antibiotics are typically costly in the absence of the drug, but bacteria can reduce this cost by acquiring compensatory mutations.
Jorge Moura de Sousa +3 more
doaj +1 more source