Results 31 to 40 of about 821,290 (231)

Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China

Microbiology Spectrum, 2023
Multidrug-resistant tuberculosis (MDR-TB) has a severe impact on public health. To investigate the drug-resistant profile, compensatory mutations and genetic variations among MDR-TB isolates, a total of 546 MDR-TB isolates from China underwent drug ...
Zexuan Song, Chunfa Liu, Wencong He, Shaojun Pei, Dongxin Liu, Xiaolong Cao, Yiting Wang, Ping He, Bing Zhao, Xichao Ou, Hui Xia, Shengfen Wang, Yanlin Zhao   +12 more
doaj   +1 more source

The genomic landscape of compensatory evolution.

PLoS Biology, 2014
Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects ...
Béla Szamecz, Gábor Boross, Dorottya Kalapis, Károly Kovács, Gergely Fekete, Zoltán Farkas, Viktória Lázár, Mónika Hrtyan, Patrick Kemmeren, Marian J A Groot Koerkamp, Edit Rutkai, Frank C P Holstege, Balázs Papp, Csaba Pál   +13 more
doaj   +1 more source

Epistatic interactions modulate the evolution of mammalian mitochondrial respiratory complex components

BMC Genomics, 2009
Background The deleterious effect of a mutation can be reverted by a second-site interacting residue. This is an epistatic compensatory process explaining why mutations that are deleterious in some species are tolerated in phylogenetically related ...
Moleirinho Ana, van Asch Barbara, Carneiro João, Azevedo Luísa, Pereira Filipe, Amorim António   +5 more
doaj   +1 more source

On the viability of Escherichia coli cells lacking DNA topoisomerase I [PDF]

, 2012
Copyright @ 2012 Stockum et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution,
Lloyd, RG, Lloyd Robert G, Rudolph Christian J, Stockum Anna, Christian J Rudolph, Stockum, A, Anna Stockum, Robert G Lloyd, Rudolph, CJ   +8 more
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Treatment-associated polymorphisms in protease are significantly associated with higher viral load and lower CD4 count in newly diagnosed drug-naive HIV-1 infected patients

Retrovirology, 2012
Background The effect of drug resistance transmission on disease progression in the newly infected patient is not well understood. Major drug resistance mutations severely impair viral fitness in a drug free environment, and therefore are expected to ...
Theys Kristof, Deforche Koen, Vercauteren Jurgen, Libin Pieter, van de Vijver David AMC, Albert Jan, Åsjö Birgitta, Balotta Claudia, Bruckova Marie, Camacho Ricardo J, Clotet Bonaventura, Coughlan Suzie, Grossman Zehava, Hamouda Osamah, Horban Andrzei, Korn Klaus, Kostrikis Leondios G, Kücherer Claudia, Nielsen Claus, Paraskevis Dimitrios, Poljak Mario, Puchhammer-Stockl Elisabeth, Riva Chiara, Ruiz Lidia, Liitsola Kirsi, Schmit Jean-Claude, Schuurman Rob, Sönnerborg Anders, Stanekova Danica, Stanojevic Maja, Struck Daniel, Van Laethem Kristel, Wensing Annemarie MJ, Boucher Charles AB, Vandamme Anne-Mieke   +34 more
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Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation.

PLoS Biology, 2021
Plasmids play an important role in bacterial genome evolution by transferring genes between lineages. Fitness costs associated with plasmid carriage are expected to be a barrier to gene exchange, but the causes of plasmid fitness costs are poorly ...
James P J Hall, Rosanna C T Wright, Ellie Harrison, Katie J Muddiman, A Jamie Wood, Steve Paterson, Michael A Brockhurst   +6 more
doaj   +1 more source

Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses [PDF]

, 2000
The immune response to HIV-1 in patients who carry human histocompatibility leukocyte antigen (HLA)-B27 is characterized by an immunodominant response to an epitope in p24 gag (amino acids 263-272, KR WIILGLNK).
Anthony D. Kelleher, Jamie Wilson, Wayne Dyer, Sunil Shaunak, Phillips, Rodney, Sullivan, JS, Ian Jones, Workman, C, Rodney E. Phillips, Edward C. Holmes, Kelleher, AD, Christopher Conlon, Rachel L. Allen, John S. Sullivan, Conlon, C, Shaunak, S, Christian Brander, Kara Olson, Goulder, Philip, Allen, RL, Dyer, W, Olson, K, Graham Ogg, Brander, C, Philip Goulder, Mcmichael, Andrew, Ogg, G, Andrew J. McMichael, Long, C, Holmes, EC, Wilson, J, Goulder, P, Cassy Workman, Sarah Rowland-Jones, Rowland-Jones, S, McMichael, AJ, Jones, I, Phillips, RE, Chad Long   +38 more
core   +1 more source

Compensatory evolution for a gene deletion is not limited to its immediate functional network

BMC Evolutionary Biology, 2009
Background Genetic disruption of an important phenotype should favor compensatory mutations that restore the phenotype. If the genetic basis of the phenotype is modular, with a network of interacting genes whose functions are specific to that phenotype ...
Bull JJ, Springman R, Harcombe WR
doaj   +1 more source

Quantitative morphology of renal cortical structures during compensatory hypertrophy [PDF]

, 1998
The compensatory hypertrophy in different renal cortical structures was studied in rats 10 and 21 days after unilateral nephrectomy (UNX). Quantitative morphological/stereological analysis revealed significant increases in total renal cortical volume ...
Giebisch, Gerhard, Pfaller, Walter, Beck, Franz-X., Ohno, Akihiro, Seppi, Thomas   +4 more
core   +1 more source

The cost of evolved constitutive lac gene expression is usually, but not always, maintained during evolution of generalist populations

Ecology and Evolution, 2021
Beneficial mutations can become costly following an environmental change. Compensatory mutations can relieve these costs, while not affecting the selected function, so that the benefits are retained if the environment shifts back to be similar to the one
Kelly N. Phillips, Tim F. Cooper
doaj   +1 more source