Results 1 to 10 of about 821,290 (231)

Novel and reported compensatory mutations in rpoABC genes found in drug resistant tuberculosis outbreaks [PDF]

Frontiers in Microbiology, 2023
BackgroundRifampicin (RIF) is a key first-line drug used to treat tuberculosis, a primarily pulmonary disease caused by Mycobacterium tuberculosis. RIF resistance is caused by mutations in rpoB, at the cost of slower growth and reduced transcription ...
Derek Conkle-Gutierrez, Sarah M. Ramirez-Busby, Bria M. Gorman, Afif Elghraoui, Sven Hoffner, Sven Hoffner, Wael Elmaraachli, Faramarz Valafar   +7 more
doaj   +6 more sources

Mobile Compensatory Mutations Promote Plasmid Survival [PDF]

mSystems, 2019
The global dissemination of plasmids encoding antibiotic resistance represents an urgent issue for human health and society. While the fitness costs for host cells associated with plasmid acquisition are expected to limit plasmid dissemination in the ...
Martin Zwanzig, Ellie Harrison, Michael A. Brockhurst, James P. J. Hall, Thomas U. Berendonk, Uta Berger   +5 more
doaj   +8 more sources

Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru [PDF]

International Journal of Mycobacteriology, 2020
Background: Rifampicin (RIF) resistance in Mycobacterium tuberculosis is frequently caused by mutations in the rpoB gene. These mutations are associated with a fitness cost, which can be overcome by compensatory mutations in other genes, among which rpoC
Ana Paula Vargas, Angela A Rios, Louis Grandjean, Daniela E Kirwan, Robert H Gilman, Patricia Sheen, Mirko J Zimic   +6 more
doaj   +5 more sources

Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis [PDF]

Scientific Reports, 2023
Resistance to isoniazid (INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control.
Gary Napier, Susana Campino, Jody E. Phelan, Taane G. Clark   +3 more
doaj   +3 more sources

Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance [PDF]

Scientific Reports
Tuberculosis (TB), caused by Mycobacterium tuberculosis, has a significant impact on global health worldwide. The development of multi-drug resistant strains that are resistant to the first-line drugs isoniazid and rifampicin threatens public health ...
Nina Billows, Jody Phelan, Dong Xia, Yonghong Peng, Taane G. Clark, Yu-Mei Chang   +5 more
doaj   +3 more sources

Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China [PDF]

BMC Microbiology
Background The global spread of rifampicin-resistant tuberculosis (RR-TB) presents a significant challenge to tuberculosis control, with compensatory mutations hypothesized to offset the fitness cost of drug resistance, thereby facilitating transmission.
Yang Che, Xiangchen Li, Dongliang Zhang, Guoxin Sang, Junli Gao, Junshun Gao, Yewei Lu, Zhengwei Liu   +7 more
doaj   +2 more sources

Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis? [PDF]

Emerging Microbes and Infections, 2018
Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear.
Qingyun Liu, Tianyu Zuo, Peng Xu, Qi Jiang, Jie Wu, Mingyu Gan, Chongguang Yang, Ravi Prakash, Guofeng Zhu, Howard E. Takiff, Qian Gao   +10 more
doaj   +2 more sources

Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study [PDF]

Microbiology Spectrum
Transmission of rifampicin-resistant and multidrug-resistant tuberculosis (MDR/RR-TB) is a major driver of the global drug-resistant TB epidemic, yet the contribution of compensatory mutations to its spread remains uncertain.
Wencong He, Yunhong Tan, Zexuan Song, Hua Bai, Peilei Hu, Xichao Ou, Bing Zhao, Xiangyi Liu, Yanlin Zhao   +8 more
doaj   +2 more sources

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda. [PDF]

PLoS ONE
Mutations in rpoB, a gene that encodes the bacterial RNA polymerase (RNAP) beta-subunit, can cause high-level resistance to rifampicin. Approximately 95% of rifampicin-resistant Mycobacterium tuberculosis clinical isolates harbour mutations in an 81-base
David Patrick Kateete, Shakira Namakula, Edgar Kigozi, Fred A Katabazi, George William Kasule, Kenneth Musisi, Edward Wampande, Deus Lukoye, Moses L Joloba   +8 more
doaj   +2 more sources

In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae [PDF]

mBio, 2018
Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone.
Leah R. Vincent, Samuel R. Kerr, Yang Tan, Joshua Tomberg, Erica L. Raterman, Julie C. Dunning Hotopp, Magnus Unemo, Robert A. Nicholas, Ann E. Jerse   +8 more
doaj   +2 more sources