Results 111 to 120 of about 1,329,175 (408)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science, EarlyView.
As a plant‐derived flavonoid, apigenin directly targets PRDX6 to inhibit its PLA2 activity, blocking HSPA8 activation and disturbing its interactions with ATM and p38MAPK in senescent cells. By dampening wide spectrum expression of the SASP, apigenin prevents loss of tissue homeostasis, improves organ function, and alleviates multiple age‐related ...
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
wiley   +1 more source

Structural and Biochemical Characterization of a Widespread Enterobacterial Peroxidase Encapsulin

Advanced Science, EarlyView.
Encapsulins are self‐assembling bacterial protein compartments loaded with cargo enzymes. The most abundant encapsulin cargo class are Dye‐decolorizing Peroxidases (DyPs). In this study, we structurally and biochemically characterize a DyP encapsulin found in many enterobacteria.
Natalia C. Ubilla‐Rodriguez, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source

Asprosin‐FABP5 Interaction Modulates Mitochondrial Fatty Acid Oxidation through PPARα Contributing to MASLD Development

Advanced Science, EarlyView.
Aided by FABP5, abnormally elevated asprosin in hepatocytes enters the nucleus, targets and inhibits PPARα binding to the CPT1A promoter, thereby suppressing FAO. Circulating asprosin exacerbates insulin resistance, collectively driving MASLD progression.
Yuan‐Yuan Yu, Min Feng, Yi Chen, Hong‐Lin Jia, Qi Zhang, Ming Tong, Yan‐Xi Li, Yu Zhao, Xin‐Xin Liu, Shi‐Feng Cao, Zheng‐kai Wang, Hou‐wei Li, Xue Liu, Yan Zhang   +13 more
wiley   +1 more source

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

Advanced Science, EarlyView.
The biosynthetic mechanism of novel natural tetramic acid S‐TeA in Alternaria alternata is elucidated. Threonine acts as a precursor for 2‐amino‐3‐methylhexanoic acid (AMHA) synthesis via eight key enzymes from the branched‐chain amino acid biosynthetic pathway in the mitochondrion, wherein three unique enzymes (IPMS, IPMDH, and ISMD) play critical ...
He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde, Shiguo Chen   +9 more
wiley   +1 more source

The Management of Human Resources Development in Increasing the Quality of Islamic Education Institutions

, 2020
Human resources are the biggest strength in the management of Islamic educational institutions. The quality of human resources is crucial right now, because competence of human resources who have knowledge and skills will be able to cope environmental ...
Elvina Rahmi, Achmad Patoni, S. Sulistyorini   +2 more
semanticscholar   +1 more source

Pengaruh Kompetensi Sumber Daya Manusia dan Pemanfaatan Teknologi Informasi terhadap Kualitas Penyajian Laporan Keuangan [PDF]

, 2018
This research intended to explore the effect of the competence of human resource and the use of technology information to financial report quality. The object of this research was SKPD Government of Empat Lawang Regency of South Sumatera Province. Sample
Indriani, P. (Poppy), Setya, H. (Haerleyawan), Terzaghi, M. T. (Muhammad)   +2 more
core  

The Influence Of Financial Management Practices, Internal Control System, Human Resources Competency And Information Technology On The Quality Of Mosque Financial Reports In Langsa City [PDF]

, 2020
— This study aims to see the effect of Financial Management Practices, Internal Control Systems, Human Resource Competence and Information Technology Utilization on the quality of financial reports partially and simultaneously.
Aulia, Aziz, Harahap, Rahmat Daim, Husni, Husni, Zainarti, Zainarti   +3 more
core   +1 more source

Competence, Motivation and Employee Performance at Baitul Maal Wa Tamwil: Influence Analysis and Recommendations for Human Resource Development

Al-Fikru
Human resources are an important element for organizational sustainability, yet organizations often face challenges in maximizing their potential. To support optimal work results, this potential must be optimized through adequate competency development ...
Muhammad ‘Isa Gautama, Puji Solikhah, Baharuddin Baharuddin   +2 more
doaj   +1 more source

Choose Your Weapon: Survival Strategies for Depressed AI Academics [PDF]

Proceedings of the IEEE, 2024, 2023
Are you an AI researcher at an academic institution? Are you anxious you are not coping with the current pace of AI advancements? Do you feel you have no (or very limited) access to the computational and human resources required for an AI research breakthrough? You are not alone; we feel the same way. A growing number of AI academics can no longer find
arxiv  

Empowering Educators: A Comprehensive Human Resources: Framework for Improving Islamic-based Schools

Journal of Islamic Education Research
This research aims to analyze human resource management strategies in Islamic-based schools. This research uses a qualitative case study type approach. Data collection techniques are carried out through interviews, observation, and documentation.
Maulidatul Hasanah, Dinda Febrianti Putri, Khoirun Nisa’, Abu Hasan   +3 more
semanticscholar   +1 more source