Results 91 to 100 of about 510,436 (298)

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

THE METHODOLOGICAL TRAINING OF FUTURE UNIVERSITY TEACHERS TO IMPLEMENT INTERCULTURAL FOREIGN LANGUAGE EDUCATION: THE COMPETENCY-BASED APPROACH

open access: yesNovìtnâ Osvìta, 2017
The article highlights peculiarities of future teacher methodological training in order to realise intercultural foreign-language education through the competency-based approach.
Nataliia Maiier
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Harnessing a knowledge worker’s competency: Lessons from the software development teams [PDF]

open access: yes, 2004
In this conceptual paper, we propose that the work force can no longer be understood only as a factor of production, but must be projected as a strategic core competency of any organization.
Sethi, Vijay, Shukla, Manasi
core  

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Research based yet action oriented: Developing individual level enterprising competencies [PDF]

open access: yes, 2007
This paper outlines an approach to teaching enterprising competencies in the university setting of Massey University, Auckland, New Zealand. It is characterised by two features.
Van Gelderen, Marco
core  

Gamification in the competence-based approach

open access: yesKANT, 2021
The rapid and widespread introduction of education based on competencies is the creation of a competent approach to learning, where the main goal is to train specialists who can skillfully respond to a rapidly changing world. The competence-based approach forces us to change the usual pedagogical beliefs that occur in the educational process: methods ...
openaire   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

COMPETENCY-BASED TRAINING IN NURSING: LIMITS AND POSSIBILITIES

open access: yesRevista da Escola de Enfermagem da USP, 2014
Objective To analyze the possibilities and limits of competency-based training in nursing. Method An integrative review of the literature on the subject was carried out, and an analysis was made of the results of a survey evaluating a nursing course ...
Silvia Franco da Rocha Tonhom   +5 more
doaj   +1 more source

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