Results 81 to 90 of about 510,436 (298)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Professional competence of translators of professionally oriented texts

open access: yesPolylinguality and Transcultural Practices, 2014
The article outlines the concepts of the competence-based approach in education and tries to define the professional translators’ competence. It shows the necessity to use the competency-based approach in education as the determiner of future effective ...
E V Gakova
doaj  

Improving the Quality of Competency-Based Assessment through a Classroom Training Activity [PDF]

open access: yesMextesol Journal, 2021
The objective of this paper is to contribute to the discussion and reflection of a classroom training activity as a method to improve the quality of competency-based assessment in the courses of Mathematics and Bahasa Indonesia.
Ikhfan Haris, Wiwy Triyanty Pulukadang, Rusmin Husain, Asni Ilham, & Gamar Abdullah
doaj  

Pengembangan Lembar Kerja Siswa Berbasis Kompetensi dalam Materi Turunan Fungsi di Sekolah Menengah Kejuruan [PDF]

open access: yes, 2016
The aims of this research are: (1) to develop competency-based student worksheet; (2) to increase student competency in understanding, applying, and solving problems with the concept of the derivative of function. This study was developmental research so
Haliman, S. (Suparjan)   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pendekatan Pembelajaran Pengetahuan Sosial Dalam Kurikulum Berbasis Kompetensi [PDF]

open access: yes, 2005
In the structure of the competency-based curriculum for junior secondary school (SMP/MTs), Social Science is offerred to grade VII, VIII, and IX, covering Economics, Geography, and History.
Enoh, M. (Mochamad)
core  

Sociocultural Competence Training in Higher Engineering Education: The Role of Gaming Simulation [PDF]

open access: yes, 2000
The present study focuses on competency-based approach in higher engineering education. Today engineers are required to be socially, culturally and communicatively skilled and able to act in constantly changing sociocultural environment.
Fricke, C.   +6 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Developing Experimental Competency in Pre-Service Physics Teachers with An Inquiry-Based Approach

open access: yesJurnal Pendidikan Fisika Indonesia
The study aims to show that an inquiry-based approach develops pre-service teachers' experimental competency. The static-group pretest-posttest design, an experimental quantitative analysis method, has been utilized.
Thanh Loan Nguyen   +2 more
doaj   +1 more source

Desain Sistem Kompensasi Gaji Pokok Berbasis Person Value Pada Perusahaan Agroindustri [PDF]

open access: yes, 2010
The oobjective of this research is to design Base Pay Compensation System that based on Person Value in order to increase internal equity within a company.
Arkeman, Y. (Yandra)   +3 more
core  

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