Results 71 to 80 of about 510,436 (298)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

THE INTRODUCTION OF THE COMPETENCE-BASED APPROACH IN EDUCATIONAL PROCESS OF TRAINING OF SKIPPERS

Ìнформаційні технології в освіті, 2017
The competence-based professional education is the objective phenomenon in education brought to life by social and economic, political and educational and pedagogical factors.
Tatyana Zaytseva
doaj  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Eksperimentasi Model Pembelajaran Kooperatif Tipe Think-pair-share (Tps) Dan Problem Based Learning (Pbl) Dengan Pendekatan Saintifik Pada Materi Bangun Ruang Sisi Datar Ditinjau Dari Kemampuan Awal Siswa SMP Kelas VIII Se-kabupaten Sragen [PDF]

, 2015
The aim of the research was to determine the effect of learning models on mathematics achievement viewed from prior competency. The learning models compared were TPS with scientific approach, PBL with scientific approach and direct learning.
Kusmayadi, T. A. (Tri), Mardiyana, M. (Mardiyana), Supriyatin, S. (Supriyatin)   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Assessment In The Workplace: A Competency-Based Approach

SA Journal of Industrial Psychology, 2002
This paper explores assessment in the workplace with a specific focus on using a competency-based approach. A normative process model for developing a competency-based assessment battery is also presented.
T. E. Potgieter, R. P. van der Merwe
doaj   +1 more source

Developing a Staged Competency Based Approach to Enterprise Creation [PDF]

, 2017
Entrepreneurialism is a concept which affects individuals in a range of different ways (Jones et al 2014). In this paper the authors are interested in exploring how entrepreneurial activity can improve a person's propensity to create new ventures and how
Bozward, David, Rogers-Draycott, Matthew Charles   +1 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

QUALITY ASSESSMENT OF STUDENT COURSEWORKS: COMPETENCY-BASED APPROACH

Образование и наука, 2018
Introduction. Today, the issues of formation and assessment of professional competencies of students of the highest professional educational institutions are widely discussed in the scientific community.
T. M. Shamsutdinova
doaj   +1 more source