Results 71 to 80 of about 28,894,011 (286)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

QUALITY ASSESSMENT OF STUDENT COURSEWORKS: COMPETENCY-BASED APPROACH

Образование и наука, 2018
Introduction. Today, the issues of formation and assessment of professional competencies of students of the highest professional educational institutions are widely discussed in the scientific community.
T. M. Shamsutdinova
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Designing A Competency Framework For Logistics Executives: The Case Of The Ready-Made Garments Manufacturers In Egypt [PDF]

The ready-made garments (RMG) manufacturing industry in Egypt is one of the main industries that supports the Egyptian economy through exports‟ earnings. Egypt‟s RMG exports are considerably less in quantity than other RMG exporting countries despite the
El-Zarka, Sara
core   +4 more sources

Professional competence of translators of professionally oriented texts

Polylinguality and Transcultural Practices, 2014
The article outlines the concepts of the competence-based approach in education and tries to define the professional translators’ competence. It shows the necessity to use the competency-based approach in education as the determiner of future effective ...
E V Gakova
doaj  

Influencing engineering education through the competency-based approach

SHS Web of Conferences, 2016
The article poses a problem of engineering education and training of today, which are facing difficulties while developing an efficient competency-based approach realization.
Ulyanova Olga V., Morozova Marina V., Nikitin Aleksandr A., Palyanov Mikhail P., Sopova Svetlana P.   +4 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

The competency-based approach as methodology of professional training of future teachers in the conditions of education informatization

, 2020
Kharkivska A.A. The competency-based approach as methodology of professional training of future teachers in the conditions of education informatization / A.A. Kharkivska // Проблеми інженерно-педагогічної освіти : зб. наук. пр. / Укр. інж.-пед. акад. – Х.
Kharkivska, Alla
core