Results 151 to 160 of about 299,250 (314)

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Identification and experimental validation of circular RNA-associated ceRNA networks in intrauterine adhesion

Frontiers in Genetics
Intrauterine adhesion (IUA) is characterized by endometrial fibrosis, posing significant risks to women’s reproductive health and fertility. This study aimed to uncover a circRNA-associated ceRNA regulatory network relevant to intrauterine adhesion (IUA),
Yajie Chang, Yajie Chang, Yajie Chang, Rui Xiang, Rui Xiang, Rui Xiang, Qi Guo, Qi Guo, Qi Guo, Jing Li, Jing Li, Jing Li, Xiaolan Li, Xiaolan Li, Xiaolan Li, Zhi Zeng, Zhi Zeng, Zhi Zeng, Jintao Peng, Jintao Peng, Jintao Peng, Xiaoyan Liang, Xiaoyan Liang, Xiaoyan Liang   +23 more
doaj   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

RNA binding protein-mediated competing endogenous RNA mechanism in cancer

Gene
It is evidently now that long non-coding RNAs (lncRNAs) play vital roles in development of cancer through versatile mechanisms. Of importance, lncRNAs play such a regulatory role often through interacting with their partners, including DNAs, RNAs or proteins.
Jingyu, Zhu, Yin-Yuan, Mo, Wan-Xin, Peng
openaire   +2 more sources

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA

Journal of experimental & clinical cancer research : CR, 2018
Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become a major obstacle in improving the clinical outcome of patients with metastatic and advanced-stage esophageal squamous cell carcinoma (ESCC).
Min Kang, M. Ren, Yan Li, Yuqiong Fu, Min Deng, Changping Li   +5 more
semanticscholar   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma

Experimental and Therapeutic Medicine, 2019
Cholangiocarcinoma (CCA) is the second most common type of primary malignancy of the liver. Certain long non-coding RNAs (lncRNAs) have been demonstrated to have key roles in tumor pathogenesis by binding to microRNAs (miRNAs). However, the competing endogenous RNA (ceRNA) network of CCA remains to be fully determined.
Fangting, Xu, Yuchong, Zhao, Gang, Qin, Ye, Huan, Longyan, Li, Wei, Gao   +5 more
openaire   +3 more sources

Long Noncoding RNA CCAT1 Functions as a Competing Endogenous RNA to Upregulate ITGA9 by Sponging MiR-296-3p in Melanoma

Cancer Management and Research, 2020
Jinghua Fan,1,2 Xiaoxiao Kang,1 Limin Zhao,1 Yan Zheng,2 Jun Yang,1 Di Li1 1Department of Dermatology, Xi’an Central Hospital Affiliated to Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of ...
Fan J, Kang X, Zhao L, Zheng Y, Yang J, Li D   +5 more
doaj  

Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma

Cancer Cell International, 2019
Background Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered a major part of the competitive endogenous RNA (ceRNA) network and have attracted growing attention.
Junyu Long, Yi Bai, Xiaobo Yang, Jianzhen Lin, Xu Yang, Dongxu Wang, Li He, Yongchang Zheng, Haitao Zhao   +8 more
doaj   +1 more source