Results 291 to 300 of about 1,773,606 (321)

Posttranscriptional Regulation of PTEN by Competing Endogenous RNAs

2015
PTEN expression can be dysregulated in cancers via multiple mechanisms including genomic loss, epigenetic silencing, transcriptional repression, and posttranscriptional regulation by microRNAs. MicroRNAs are short, noncoding RNAs that regulate gene expression by binding to recognition sites on target transcripts.
Yvonne, Tay, Pier Paolo, Pandolfi
openaire   +2 more sources

Competing Endogenous RNAs in Hepatocellular Carcinoma—The Pinnacle of Rivalry

Seminars in Liver Disease, 2019
AbstractThe role of noncoding transcripts in gene expression is nowadays acknowledged to keep various diseases at bay—despite being referred to as “junk” DNA several years ago. Believed to be at the heart of multiple regulatory pathways, microRNAs (miRNAs) are small noncoding RNAs (ncRNAs) involved in posttranscriptional gene regulation.
Abdelrahman Yousry, Afify, Salma Abdulmaqsoud, Ibrahim, Mennah Hisham, Aldamsisi, Mai Saad, Zaghloul, Nada, El-Ekiaby, Ahmed Ihab, Abdelaziz   +5 more
openaire   +2 more sources

Mimicry, deception and competition: The life of competing endogenous RNAs

WIREs RNA, 2019
Since their discovery, small regulatory RNAs (sRNAs) were thought to be regulated exclusively at the transcriptional level. However, accumulating data from recent reports indicate that posttranscriptional signals can also modulate the function and stability of sRNAs.
Marc P, Grüll, Eric, Massé
openaire   +2 more sources

Characterization of conditions for competing endogenous RNA regulation in GBM

2013 IEEE International Workshop on Genomic Signal Processing and Statistics, 2013
Summary form only given. MicroRNAs (miRNAs) are short non-coding RNAs with the average length of 22 nucleotides. They are known to induce mRNA degradation or suppression of translation by complementarily binding to 3' untranslated regions (3' UTRs) of target mRNA transcripts.
Yu-Chiao Chiu, Eric Y. Chuang, Tzu-Hung Hsiao, Yidong Chen 0002   +3 more
openaire   +1 more source

Competing Endogenous RNAs (CeRNAs): Novel Network in Neurological Disorders

Current Medicinal Chemistry, 2021
Neurological disorders (NDs) comprise a broad range of diseases affecting both central and peripheral nervous systems. These complex multifactorial diseases have a high rate of mortality all over the world, particularly in aged people. Today, new evidence drove our attention to the notable role of noncoding RNAs (ncRNAs) in the progression of NDs ...
Sadra Samavarchi Tehrani, Reyhane Ebrahimi, Atiyeh Al-e-Ahmad, Ghodratollah Panahi, Reza Meshkani, Simin Younesi, Payam Saadat, Hadi Parsian   +7 more
openaire   +2 more sources

Long non-coding RNA H19 and cancer: A competing endogenous RNA

Bulletin du Cancer, 2019
Long non-coding RNA (lncRNA) is a class of non-coding RNA with a length of more than 200 nucleotides, which has become a hotspot in the research of tumorigenesis and development in recent years. Accumulating studies have indicated that H19 is abnormally expressed in human malignant tumors, and regulates cell proliferation, migration, invasion, anti ...
Yafen, Ye, Ao, Shen, Anwen, Liu
openaire   +2 more sources

CircRNA-104718 acts as competing endogenous RNA and promotes hepatocellular carcinoma progression through microRNA-218-5p/TXNDC5 signaling pathway.

Clinical science, 2019
Accumulating evidences indicate that circular RNAs (circRNAs) play a vital role in diverse cancer biology. However, the contributions of circRNAs to hepatocellular carcinoma (HCC) and their underlying mechanism remain largely unknown.
Jia-Ze Yu, Minjie Yang, Bo Zhou, Jianjun Luo, Zihan Zhang, Wen Zhang, Zhiping Yan   +6 more
semanticscholar   +1 more source

Roles of microRNAs and prospective view of competing endogenous RNAs in mycotoxicosis

Mutation Research/Reviews in Mutation Research, 2019
Mycotoxins, produced by fungi, are secondary metabolites causing adverse, toxic and pathological effects on human and animals. Studies about the association between mycotoxins and microRNAs (miRNAs) were developed since miRNAs have been demonstrated to play a critical role in many developmental processes for regulating messenger RNA (mRNA).
Yuxiao Liao, Zhao Peng, Liangkai Chen, Liegang Liu, Qinghua Wu, Wei Yang   +5 more
openaire   +2 more sources

Competing Endogenous RNA and Interactome Bioinformatic Analyses on Human Telomerase

Rejuvenation Research, 2014
We present a classic interactome bioinformatic analysis and a study on competing endogenous (ce) RNAs for hTERT . The hTERT gene codes for the catalytic subunit and limiting component of the human telomerase complex.
Walter, Arancio, Giuseppe, Pizzolanti, Swonild Ilenia, Genovese, Concetta, Baiamonte, Carla, Giordano   +4 more
openaire   +2 more sources

Role of exosomal competing endogenous RNA in patients with hepatocellular carcinoma

Journal of Cellular Biochemistry, 2018
AbstractRecent research has tried to use exosomal RNAs (coding and noncoding) as potential diagnostic markers for hepatocellular carcinoma (HCC). Initially, by using bioinformatics, we selected an HCC‐exosomal RNA‐based biomarker panel. The choice of this panel depends on the integration of Ras‐related in brain (RAB11A) gene expression and its ...
Asmaa Abd El Gwad, Marwa Matboli, Ahmed El‐Tawdi, Eman K. Habib, Hanan Shehata, Doaa Ibrahim, Fathy Tash   +6 more
openaire   +2 more sources