Results 111 to 120 of about 83,602 (280)

Unveiling Lactylation: A Novel Frontier in Cancer Stemness and Therapy

Advanced Science, EarlyView.
Tumor metabolism and epigenetic regulation are intrinsically linked. This review highlights lactylation as a pivotal bridge connecting these processes, acting as an active epigenetic effector in cancer stemness. We delineate how lactylation orchestrates the cancer stem cell landscape and evaluate its regulatory networks.
Ting Li, Hongyu Gu, Chang Liu, Yuesheng Lv, Feifei Li, Liang Liang, Jia Yi, Xuanyi Wang, Yi Zhun Zhu, Chuan Xu   +9 more
wiley   +1 more source

Supplementary Material for: Identifying Molecular Markers of Cervical Cancer Based on Competing Endogenous RNA Network Analysis [PDF]

, 2019
Aim: Recurrence being a major challenge for the treatment of cervical cancer, we aimed at identifying novel molecular markers of cervical cancer to improve recurrence prediction. Methods: Cervical cancer samples were obtained from the Cancer Genome Atlas.
Yu J. (3610580), Zhang T. (2831351), Shi C. (4131748), Gao Y. (3237477), Yang Y. (3237684), Qin S. (4668562), Zhang L. (3112731)   +6 more
core   +1 more source

Noncoding RNA-associated competing endogenous RNA networks in trastuzumab-induced cardiotoxicity

Non-coding RNA Research
Trastuzumab-induced cardiotoxicity (TIC) is a common and serious disease with abnormal cardiac function. Accumulating evidence has indicated certain non-coding RNAs (ncRNAs), functioning as competing endogenous RNAs (ceRNAs), impacting the progression of cardiovascular diseases.
Suifen Xie, Ni Zhou, Nan Su, Zijun Xiao, Shanshan Wei, Yuanying Yang, Jian Liu, Wenqun Li, Bikui Zhang   +8 more
openaire   +3 more sources

Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives

Oncotarget, 2016
Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is proposed recently.
Yang, Chao, Wu, Di, Gao, Lin, Liu, Xi, Jin, Yinji, Wang, Dong, Wang, Tianzhen, Li, Xiaobo   +7 more
openaire   +3 more sources

Transcriptome reveals the roles and potential mechanisms of CeRNA in the regulation of salivary gland development in the tick Rhipicephalus haemaphysaloides

Frontiers in Cellular and Infection Microbiology
IntroductionThe salivary glands of female ticks rapidly degenerate after feeding. The mechanism involves programmed cell death mediated by an ecdysteroid receptor.
Shanming Hu, Songqin Chen, Haotian Zhu, Yanan Wang, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Jinlin Zhou   +7 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression

Journal of Hematology & Oncology, 2018
Background Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation.
Yang Li, Changqian Zeng, Jialei Hu, Yue Pan, Yujia Shan, Bing Liu, Li Jia   +6 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Integrated analysis of competing endogenous RNA network revealing potential prognostic biomarkers of hepatocellular carcinoma [PDF]

, 2019
Objective: The goal of our study is to identify a competing endogenous RNA (ceRNA) network using dysregulated RNAs between HCC tumors and the adjacent normal liver tissues from The Cancer Genome Atlas (TCGA) datasets, and to investigate underlying ...
Liu, Zhengtao, Huang, Jianly,, Su, Hao, Liu, Zhengqian,, Han, Quanfa, Qin, Wei,, Zhou, Xin,, Liu, Xiaoguang, Qin, Wei, Han, Bowen, O\u27Brien, Stephen J., Yu, Tingdong, Wang, Xiangkun,, Liu, Zhengtao,, Liao, Xiwen, Zeng, Xianmin,, Liu, Zhengqian, Yu, Long,, Peng, Tao, Zhou, Xin, O'Brien, Stephen J.,, Ye, Xinping,, Yu, Long, Han, Chuangye,, Ye, Xinping, Peng, Tao,, Deng, Jianlong, Winkler, Cheryl A.,, Han, Chuangye, Gong, Yizhen,, Yang, Chengkun,, Huang, Ketuan,, Deng, Jianlong,, Winkler, Cheryl A., Yang, Chengkun, Zhu, Guangzhi, Huang, Jianlv, Liu, Xiaoguang,, Su, Hao,, Yu, Tingdong,, Gong, Yizhen, Han, Bowen,, Zeng, Xianmin, Huang, Rui, Han, Quanfa,, Huang, Ketuan, Liao, Xiwen,, Huang, Rui,, Wang, Xiangkun, Zhu, Guangzhi,   +49 more
core   +1 more source

Competing endogenous RNA networks in the epithelial to mesenchymal transition in diffuse-type of gastric cancer [PDF]

, 2020
The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ZEB1/2, Snail, Slug, and Twist1 ...
Santoro, Pablo, Gonzalo Carrasco-Avino, Corvalán, Alejandro H., Alejandro H. Corvalan, Landeros Pérez, Natalia, Carrasco Aviño, Gonzalo, Natalia Landeros, Pablo M. Santoro   +7 more
core   +1 more source