Results 1 to 10 of about 697,227 (280)
A highly sensitive bead-based flow cytometric competitive binding assay to detect SARS-CoV-2 neutralizing antibody activity [PDF]
Frontiers in Immunology, 2022 Accurate detection of SARS-CoV-2 neutralizing antibody (nAb) is critical for assessing the immunity levels after virus infection or vaccination. As fast, cost-effective alternatives to viral infection-based assays, competitive binding (CB) assays were ...
Xiangyu Yao +17 more
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A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies [PDF]
mAbs, 2022 Therapeutic monoclonal antibodies (mAbs) have a propensity to host a large number of chemical and enzymatical modifications that need to be properly assessed for their potential impact on target binding.
Zhengqi Zhang +3 more
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bindNode24: Competitive binding residue prediction with 60 % smaller model [PDF]
Computational and Structural Biotechnology JournalMany proteins function through ligand binding. Yet, reliable experimental binding data remains limited. Recent advances predict binding residues from sequences using protein Language Model embeddings.
Kyra Erckert +2 more
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CLASP-mediated competitive binding in protein condensates directs microtubule growth [PDF]
Nature CommunicationsMicrotubule organization in cells relies on targeting mechanisms. Cytoplasmic linker proteins (CLIPs) and CLIP-associated proteins (CLASPs) are key regulators of microtubule organization, yet the underlying mechanisms remain elusive. Here, we reveal that
Xuanyan Jia +11 more
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mBio, 2022 Although the phosphorothioate (PT) modification, in which the nonbridging oxygen in the DNA sugar-phosphate backbone is replaced by sulfur, has been reported to play versatile roles in multiple cellular processes, very little data have been obtained to ...
You Tang +10 more
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Validating a re-implementation of an algorithm to integrate transcriptome and ChIP-seq data [PDF]
PeerJ, 2023 Transcription factor binding to a gene regulatory region induces or represses its expression. Binding and expression target analysis (BETA) integrates the binding and gene expression data to predict this function.
Mahmoud Ahmed, Deok Ryong Kim
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Non-microRNA binding competitively inhibits LIN28 regulation [PDF]
Cell Reports, 2021 RNA binding protein (RBP) expression is finite. For RBPs that are vastly outnumbered by their potential target sites, a simple competition for binding can set the magnitude of post-transcriptional control. Here, we show that LIN28, best known for its direct regulation of let-7 miRNA biogenesis, is also indirectly regulated by its widespread binding of ...
Frederick E. Tan +3 more
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A Polarity-Sensitive Far-Red Fluorescent Probe for Glucose Sensing through Skin
Biosensors, 2023 The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important to continuously track the glucose level to provide better management of the disease.
Lydia Colvin +4 more
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Journal of Functional Biomaterials, 2023 Currently available hemodialysis (HD) membranes are unable to safely remove protein-bound uremic toxins (PBUTs), especially those bonded to human serum albumin (HSA).
Madalena Lopes +3 more
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Competition between LIM-binding domains [PDF]
Biochemical Society Transactions, 2008 LMO (LIM-only) and LIM-HD (LIM-homeodomain) proteins form a family of proteins that is required for myriad developmental processes and which can contribute to diseases such as T-cell leukaemia and breast cancer. The four LMO and 12 LIM-HD proteins in mammals are expressed in a combinatorial manner in many cell types, forming a transcriptional ‘LIM code’
Matthews, Jacqueline +8 more
openaire +4 more sources