Results 11 to 20 of about 697,227 (280)

Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding

mAbs, 2021
Chemical modifications (attributes) in the binding regions of stressed therapeutic proteins may affect binding to target and efficacy of therapeutic proteins.
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Arnold McAuley, Margaret S. Ricci, Pavel V. Bondarenko   +5 more
doaj   +1 more source

Experimental and Computational Investigation on the Interaction of Anticancer Drug Gemcitabine with Human Plasma Protein: Effect of Copresence of Ibuprofen on the Binding

Molecules, 2022
The interaction of common anticancer drug gemcitabine with human serum albumin (HSA) has been studied in detail. The effect of an omnipresent nonsteroidal anti-inflammatory drug ibuprofen was also seen on the binding of HSA and gemcitabine.
Mohd Sajid Ali, Hamad A. Al-Lohedan
doaj   +1 more source

Molecular Additives as Competitive Binding Agents to Control Supramolecular-Driven Nanoparticle Assembly [PDF]

ACS Nanoscience Au
Rebecca L. Li, Nicholas Sbalbi, Matthew Ye, Robert J. Macfarlane   +3 more
doaj   +2 more sources

Investigating cannabinoids as P2X purinoreceptor 4 ligands by using surface plasmon resonance and computational docking

Heliyon, 2023
P2X purinoceptor 4 (P2X4) is an ATP-gated ion channel receptor with diverse neurophysiological functions, and P2X4 modulators hold promise as potential therapeutics for neuropathic pain, neuroinflammation, and neurodegenerative diseases.
Tess Puopolo, Ang Cai, Chang Liu, Hang Ma, Navindra P. Seeram   +4 more
doaj   +1 more source

Diffusion-induced competitive two-site binding [PDF]

The Journal of Chemical Physics, 2019
The influence of diffusion on the kinetics of ligand binding to a macromolecule with two sites is considered for a simple model where, in the reaction-controlled limit, there is no cooperativity and hence the sites are independent. By applying our recently developed formalism to describe a network of coupled diffusion-influenced reactions, we show that
Irina V. Gopich, Attila Szabo
openaire   +2 more sources

Competitive aptamer switch for modulating ligand binding affinity

Advanced Agrochem, 2023
Aptamers are short, single-stranded DNA or RNA molecules that selectively bind to a target molecule. Aptamer-complement duplex (ACD) is often used to design molecular switches capable of producing a detectable signal or triggering a structural change ...
Derek Puyat, Sung Won Oh, Shiming Liu, Jinglin Fu, Ph.D   +3 more
doaj   +1 more source

Is styrene competitive for dopamine receptor binding?

Biomolecular Concepts, 2022
The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations.
De Santis Emiliano, Minicozzi Velia, Rossi Giancarlo, Stellato Francesco, Morante Silvia   +4 more
doaj   +1 more source

In Vitro Evaluation of Fluorescence Glucose Biosensor Response

Sensors, 2014
Rapid, accurate, and minimally-invasive glucose biosensors based on Förster Resonance Energy Transfer (FRET) for glucose measurement have the potential to enhance diabetes control.
Mamdouh Aloraefy, T. Joshua Pfefer, Jessica C. Ramella-Roman, Kim E. Sapsford   +3 more
doaj   +1 more source

Computational fragment-based binding site identification by ligand competitive saturation. [PDF]

PLoS Computational Biology, 2009
Fragment-based drug discovery using NMR and x-ray crystallographic methods has proven utility but also non-trivial time, materials, and labor costs.
Olgun Guvench, Alexander D MacKerell
doaj   +1 more source

Structure of human transthyretin complexed with bromophenols: a new mode of binding [PDF]

, 2000
The binding of two organohalogen substances, pentabromophenol (PBP) and 2,4,6-tribromophenol (TBP), to human transthyretin (TTR), a thyroid hormone transport protein, has been studied by in vitro competitive binding assays and by X-ray crystallography ...
Bergman, A, Brouwer, A, Cook, Atlanta, Ghosh, M, Johnson, L N, Meerts, I A   +5 more
core   +2 more sources