Kinetic and thermodynamic analysis of leech-derived tryptase inhibitor interaction with bovine tryptase and bovine trypsin [PDF]
, 2000 The interaction of leech-derived tryptase inhibitor (LDTI) with bovine liver capsule tryptase (BLCT) and bovine trypsin has been studied using both thermodynamic and kinetic approaches.
Auerswald E.A. +6 more
core +1 more source
Competitive ELISA for Protein-lipopolysaccharide (LPS) Binding
Bio-Protocol, 2014 Lipopolysaccharide is the major constituent of the outer membrane of gram-negative bacteria and, once released from the bacterial surface into the bloodstream, is a potent activator of the host immune system, which can lead to septic shock.
Victoria Martínez-Sernández +1 more
doaj +1 more source
Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70
Molecules, 2022 Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HSP70s
Suzanne O’Connor +10 more
doaj +1 more source
Competitive Carboxylate–Silicate Binding at Iron Oxyhydroxide Surfaces [PDF]
Langmuir, 2021 Dissolved silicate ions in wet and dry soils can determine the fate of organic contaminants via competitive binding. While fundamental surface science studies have advanced knowledge of binding in competitive systems, little is still known about the ranges of solution conditions, the time dependence, and the molecular processes controlling competitive ...
Cheng, Wei +3 more
openaire +5 more sources
Model mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids [PDF]
, 2013 The aim of the study is to reveal molecular mechanisms of possible activity modulation of antimicrobial bis-quaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the ...
Gömöry, Ágnes +3 more
core +2 more sources
Contribution of fibronectin-binding protein to pathogenesis of Streptococcus suis serotype 2 [PDF]
, 2002 In the present study we investigated the role of the fibronectin (FN)- and fibrinogen (FGN)-binding protein (FBPS) in the pathogenesis of Streptococcus suis serotype 2 in piglets. The complete gene encoding FBPS from S.
Greeff, A., de +5 more
core +2 more sources
Competitive interactions of ligands and macromolecular crowders with maltose binding protein. [PDF]
PLoS ONE, 2013 Cellular signaling involves a cascade of recognition events occurring in a complex environment with high concentrations of proteins, polysaccharides, and other macromolecules.
Andrew C Miklos +2 more
doaj +1 more source
Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]
, 2015 Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D +8 more
core +2 more sources
Thermodynamics of competitive molecular channel transport: application to artificial nuclear pores. [PDF]
PLoS ONE, 2010 In an analytical model channel transport is analyzed as a function of key parameters, determining efficiency and selectivity of particle transport in a competitive molecular environment.
Wolfgang R Bauer, Walter Nadler
doaj +1 more source
IUCrJ, 2021 Death-associated protein kinase 1 (DAPK1) is a large multidomain protein with an N-terminal serine/threonine protein kinase domain. DAPK1 is considered to be a promising molecular target for the treatment of Alzheimer's disease (AD). In the present study,
Takeshi Yokoyama +2 more
doaj +1 more source