Results 101 to 110 of about 1,613,954 (310)

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Immunoglobulin deposition on biomolecule corona determines complement opsonisation efficiency of preclinical and clinical nanoparticles

Nature Nanotechnology, 2019
Deposition of complement factors (opsonization) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood.
V. Vu, Geoffrey B. Gifford, Fangfang Chen, Halli Benasutti, Guankui Wang, E. Groman, R. Scheinman, L. Saba, S. Moghimi, D. Simberg   +9 more
semanticscholar   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Complement in neurobiology

Frontiers in Bioscience, 2011
The complement (C) system is a vital arm of innate immunity with many roles, including control of inflammation. This article examines the (C) system with emphasis on recent developments on complement relevant to neurobiology, in particular regarding our understanding and treatment of immune-mediated diseases.
Lawrence L, Horstman, Wenche, Jy, Yeon S, Ahn, Amir H, Maghzi, Masoud, Etemadifar, J Steven, Alexander, Jeanie C, McGee, Alireza, Minagar   +7 more
openaire   +2 more sources

Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Science Translational Medicine, 2017
C3 deficiency protects against hippocampal neurodegeneration and cognitive decline in aged APP/PS1 mice despite abundant Aβ plaques. Avoiding complements Complement C3 is an immune molecule that protects against pathogens and plays a role in refinement ...
Qiaoqiao Shi, Saba J Chowdhury, Rong Ma, Kevin X. Le, Soyon Hong, B. Caldarone, Beth Stevens, C. Lemere   +7 more
semanticscholar   +1 more source

Effects of Climatic Conditions and Genotypes on Vitamin C Levels in Stone Species and Apple Cultivars

Plants
Genetic and climatic factors influence the nutritional content of fruit, with vitamin C being a key component. Using HPLC, we quantified the amount of vitamin C in cherries, apricots, plums, and apples from 2022 to 2024.
Aneta Bílková, Pavol Suran, Dáša Jiroušová, Lucie Šepsová, Martin Mészáros   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Intermediate monocytes induced by IFN-γ inhibit cancer metastasis by promoting NK cell activation through FOXO1 and interleukin-27

Journal for ImmunoTherapy of Cancer, 2022
Yunfeng Liu, Rikang Wang, Weili Bao, Mouli Pal, Karina Yazdanbakhsh, Hui Zhong   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source