Results 111 to 120 of about 1,441,098 (322)

The role of the complement system in cancer

Journal of Clinical Investigation, 2017
In addition to being a component of innate immunity and an ancient defense mechanism against invading pathogens, complement activation also participates in the adaptive immune response, inflammation, hemostasis, embryogenesis, and organ repair and ...
V. Afshar-Kharghan
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility

eLife, 2014
Genome-wide association studies have found variation within the complement factor H gene family links to host susceptibility to meningococcal disease caused by infection with Neisseria meningitidis (Davila et al., 2010).
Joseph JE Caesar, Hayley Lavender, Philip N Ward, Rachel M Exley, Jack Eaton, Emily Chittock, Talat H Malik, Elena Goiecoechea De Jorge, Matthew C Pickering, Christoph M Tang, Susan M Lea   +10 more
doaj   +1 more source

On additive complement of a finite set [PDF]

arXiv, 2013
We say the sets of nonnegative integers A and B are additive complements if their sum contains all sufficiently large integers. In this paper we prove a conjecture of Chen and Fang about additive complement of a finite set.
arxiv  

Concerning the Mechanism of Complement Action [PDF]

, 1956
Elmer L. Becker
openalex   +1 more source

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Voclosporin and the Antiviral Effect Against SARS-CoV-2 in Immunocompromised Kidney Patients

Kidney International Reports, 2023
Introduction: Immunocompromised kidney patients are at increased risk of prolonged SARS-CoV-2 infection and related complications. Preclinical evidence demonstrates a more potent inhibitory effect of voclosporin on SARS-CoV-2 replication than tacrolimus ...
Eline J. Arends, Soufian Meziyerh, Dirk Jan A.R. Moes, Sylvia W.A. Kamerling, Sandra van der Kooy, Natacha S. Ogando, Eric J. Snijder, Martijn van Hemert, Leo G. Visser, Mariet C.W. Feltkamp, Eric C.J. Claas, Ton J. Rabelink, Cees van Kooten, Aiko P.J. de Vries, Y.K. Onno Teng   +14 more
doaj  

Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases

Frontiers in Immunology, 2016
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune complex-mediated ...
Katherine eLintner, Yee Ling eWu, Yan eYang, Charles eSpencer, Georges eHauptmann, Lee eHebert, John eAtkinson, Chack-Yung eYu   +7 more
doaj   +1 more source

Complementable Operators and their Schur Complements [PDF]

arXiv
In this paper, we characterize complementable operators and provide more precise expressions for the Schur complement of these operators using a single Douglas solution. We demonstrate the existence of subspaces where the given operator is invariably complementable. Additionally, we investigate the range-Hermitian property of these operators.
arxiv  

On the Laurent coefficients of the Riemann map for the complement of the Mandelbrot set [PDF]

arXiv, 2014
We straighten a result of [5] about arithmetic properties of the Laurent coefficients of the conformal isomorphism from the complement of the unit disk onto the complement of the Mandelbrot set. This confirms an empirical observation by Don Zagier, see [1]
arxiv