Results 11 to 20 of about 3,211,899 (373)
Complement system part I - molecular mechanisms of activation and regulation
Frontiers in Immunology, 2015 Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Nicolas eMerle +3 more
doaj +2 more sources
Complement in trauma—Traumatised complement? [PDF]
British Journal of Pharmacology, 2020 Physical trauma represents a major global burden. The trauma‐induced response, including activation of the innate immune system, strives for regeneration but can also lead to post‐traumatic complications. The complement cascade is rapidly activated by damaged tissue, hypoxia, exogenous proteases and others.
Christian Karl Braun +5 more
openaire +3 more sources
Complosome — the intracellular complement system
Nature Reviews Nephrology, 2023 The complement system is a recognized pillar of host defence against infection and noxious self-derived antigens. Complement is traditionally known as a serum-effective system, whereby the liver expresses and secretes most complement components, which ...
E. West, C. Kemper
semanticscholar +1 more source
medRxiv, 2020 Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response that fuels hyper-inflammation and thrombotic microangiopathy increasing the mortality rate in coronavirus disease 2019 (COVID-19).
P. Skendros +16 more
semanticscholar +1 more source
Complement as a target in COVID-19?
Nature reviews. Immunology, 2020 There is an urgent need to develop effective therapies for COVID-19. Here, we urge immunologists and clinicians to consider the potential of targeting the complement system in these patients. This Comment article from Lambris and colleagues considers the
A. Risitano +6 more
semanticscholar +1 more source
The state of complement in COVID-19
Nature reviews. Immunology, 2021 Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute ...
B. Afzali +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 The classical liver-derived and serum-effective complement system is well appreciated as a key mediator of host protection via instruction of innate and adaptive immunity.
Natalia Kunz +2 more
doaj +1 more source
Detection and characterisation of Complement protein activity in bovine milk by bactericidal sequestration assay [PDF]
, 2015 Susan Maye is in receipt of a Teagasc Walsh Fellowship. Financial support by the Department of Agriculture, Food and the Marine is gratefully acknowledged.Copyright © Proprietors of Journal of Dairy Research 2015 (Institute of Food Research and the ...
Fitzgerald, Gerald F +3 more
core +1 more source
The complement system in age-related macular degeneration
Cellular and Molecular Life Sciences, 2021 Age-related macular degeneration (AMD) is a chronic and progressive degenerative disease of the retina, which culminates in blindness and affects mainly the elderly population.
A. Armento, M. Ueffing, Simon J. Clark
semanticscholar +1 more source
The complement system in COVID-19: friend and foe?
JCI Insight, 2020 COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality has been attributed to an exaggerated immune response.
A. Java +6 more
semanticscholar +1 more source