Results 11 to 20 of about 1,441,098 (322)
medRxiv, 2020 Emerging data indicate that complement and neutrophils are involved in the maladaptive host immune response that fuels hyper-inflammation and thrombotic microangiopathy increasing the mortality rate in coronavirus disease 2019 (COVID-19).
P. Skendros +16 more
semanticscholar +1 more source
Complement as a target in COVID-19?
Nature reviews. Immunology, 2020 There is an urgent need to develop effective therapies for COVID-19. Here, we urge immunologists and clinicians to consider the potential of targeting the complement system in these patients. This Comment article from Lambris and colleagues considers the
A. Risitano +6 more
semanticscholar +1 more source
The state of complement in COVID-19
Nature reviews. Immunology, 2021 Hyperactivation of the complement and coagulation systems is recognized as part of the clinical syndrome of COVID-19. Here we review systemic complement activation and local complement activation in response to the causative virus severe acute ...
B. Afzali +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 The classical liver-derived and serum-effective complement system is well appreciated as a key mediator of host protection via instruction of innate and adaptive immunity.
Natalia Kunz +2 more
doaj +1 more source
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Science, 2016 Too much cleaning up The complement system and microglia seek out and destroy unwanted cellular debris for the peripheral immune system as well as excess synapses in the developing brain. Hong et al. now show how the system may go haywire in adults early
Soyon Hong +12 more
semanticscholar +1 more source
The complement system in COVID-19: friend and foe?
JCI Insight, 2020 COVID-19, the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality has been attributed to an exaggerated immune response.
A. Java +6 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated to trigger this detrimental process.
J. Holter +31 more
semanticscholar +1 more source
Immunity, endothelial injury and complement-induced coagulopathy in COVID-19
Nature Reviews Nephrology, 2020 In December 2019, a novel coronavirus was isolated from the respiratory epithelium of patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a pathogenic condition ...
Luca Perico +5 more
semanticscholar +1 more source
The complement system in age-related macular degeneration
Cellular and Molecular Life Sciences, 2021 Age-related macular degeneration (AMD) is a chronic and progressive degenerative disease of the retina, which culminates in blindness and affects mainly the elderly population.
A. Armento, M. Ueffing, Simon J. Clark
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 Leptospirosis is considered one of the most important zoonosis worldwide. The activation of the Complement System is important to control dissemination of several pathogens in the host.
Íris A. de Castro +8 more
doaj +1 more source