Results 21 to 30 of about 3,211,899 (373)

Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans

Frontiers in Cellular and Infection Microbiology, 2018
Leptospirosis is considered one of the most important zoonosis worldwide. The activation of the Complement System is important to control dissemination of several pathogens in the host.
Íris A. de Castro, Lorena Bavia, Tatiana R. Fraga, Mariane T. Amano, Leandro C. D. Breda, Adriana P. Granados-Martinez, Ana M. G. da Silva, Silvio A. Vasconcellos, Lourdes Isaac   +8 more
doaj   +1 more source

Complement activation and protein adsorption by carbon nanotubes [PDF]

, 2006
As a first step to validate the use of carbon nanotubes as novel vaccine or drug delivery devices, their interaction with a part of the human immune system, complement, has been explored.
Flahaut, Emmanuel, Green, Malcolm L. H., Salvador-Morales, Carolina, Sim, Edith, Sim, Robert B., Sloan, Jeremy   +5 more
core   +2 more sources

Highly Sensitive Flow Cytometric Detection of Residual B-Cells After Rituximab in Anti-Neutrophil Cytoplasmic Antibodies-Associated Vasculitis Patients

Frontiers in Immunology, 2020
BackgroundB-cell depletion with rituximab (RTX) is an effective treatment for anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.
Laura S. van Dam, Jelle M. Oskam, Sylvia W. A. Kamerling, Eline J. Arends, O. W. Bredewold, Magdalena A. Berkowska, Jacques J. M. van Dongen, Ton J. Rabelink, Cees van Kooten, Y. K. Onno Teng   +9 more
doaj   +1 more source

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The new SARS-CoV-2 pandemic leads to COVID-19 with respiratory failure, substantial morbidity, and significant mortality. Overactivation of the innate immune response is postulated to trigger this detrimental process.
J. Holter, S. Pischke, Eline de Boer, A. Lind, S. Jenum, A. R. Holten, K. Tonby, A. Barratt-Due, Marina Sokolova, C. Schjalm, V.Ye. Chaban, Anette Kolderup, T. Tran, Torleif Tollefsrud Gjølberg, L. Skeie, Liv Hesstvedt, Vidar Ormåsen, B. Fevang, C. Austad, Karl Erik Müller, C. Fladeby, M. Holberg-Petersen, B. Halvorsen, F. Müller, P. Aukrust, S. Dudman, T. Ueland, J. Andersen, F. Lund-Johansen, Lars Heggelund, A. Dyrhol-Riise, T. Mollnes   +31 more
semanticscholar   +1 more source

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney International Reports, 2018
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering   +9 more
doaj   +1 more source

Sublytic Terminal Complement Components Induce Eryptosis in Autoimmune Haemolytic Anaemia Related to IgM Autoantibodies [PDF]

, 2019
BACKGROUND/AIMS: Eryptosis, the suicidal death of red blood cells (RBCs), is characterized by phosphatidylserine (PS) exposure at the cell surface. It can be catalysed by a variety of abnormal conditions and diseases.
Balola, Abdelwahab Hassan Ahmed, Bartolmäs, Thilo, Mayer, Beate, Salama, Abdulgabar   +3 more
core   +1 more source

Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

Nature Reviews Nephrology, 2020
In December 2019, a novel coronavirus was isolated from the respiratory epithelium of patients with unexplained pneumonia in Wuhan, China. This pathogen, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes a pathogenic condition ...
Luca Perico, A. Benigni, F. Casiraghi, L. Ng, L. Rénia, G. Remuzzi   +5 more
semanticscholar   +1 more source

Complement C3 serum levels in anorexia nervosa: a potential biomarker for the severity of disease? [PDF]

, 2011
BackgroundAnorexia nervosa carries the highest mortality rate of any psychiatric disorder. Even the most critically ill anorexic patients may present with normal 'standard' laboratory values, underscoring the need for a new sensitive biomarker.
Flierl, Michael A, Gaudiani, Jennifer L, Long, Carlin S, Mehler, Philip S, Sabel, Allison L, Stahel, Philip F   +5 more
core   +2 more sources

Schizophrenia risk from complex variation of complement component 4

Nature, 2016
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia’s strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular ...
Aswin Sekar, Allison R. Bialas, H. de Rivera, Avery Davis, Timothy R. Hammond, Nolan Kamitaki, Katherine Tooley, J. Presumey, M. Baum, Vanessa Van Doren, G. Genovese, Samuel A. Rose, R. Handsaker, M. Daly, M. Carroll, B. Stevens, S. Mccarroll   +16 more
semanticscholar   +1 more source

Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial

Trials, 2022
Background Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity.
Mieke van Schaik, Eline J. Arends, Darius Soonawala, Ellen van Ommen, Karina de Leeuw, Maarten Limper, Pieter van Paassen, Tom W. J. Huizinga, René E. M. Toes, Cees van Kooten, Joris I. Rotmans, Ton J. Rabelink, Y. K. Onno Teng   +12 more
doaj   +1 more source