Results 21 to 30 of about 1,441,098 (322)

Highly Sensitive Flow Cytometric Detection of Residual B-Cells After Rituximab in Anti-Neutrophil Cytoplasmic Antibodies-Associated Vasculitis Patients

Frontiers in Immunology, 2020
BackgroundB-cell depletion with rituximab (RTX) is an effective treatment for anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) patients.
Laura S. van Dam, Jelle M. Oskam, Sylvia W. A. Kamerling, Eline J. Arends, O. W. Bredewold, Magdalena A. Berkowska, Jacques J. M. van Dongen, Ton J. Rabelink, Cees van Kooten, Y. K. Onno Teng   +9 more
doaj   +1 more source

Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

Kidney International Reports, 2018
IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal ...
Nicholas R. Medjeral-Thomas, Anne Troldborg, Nicholas Constantinou, Hannah J. Lomax-Browne, Annette G. Hansen, Michelle Willicombe, Charles D. Pusey, H. Terence Cook, Steffen Thiel, Matthew C. Pickering   +9 more
doaj   +1 more source

Schizophrenia risk from complex variation of complement component 4

Nature, 2016
Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia’s strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular ...
Aswin Sekar, Allison R. Bialas, H. de Rivera, Avery Davis, Timothy R. Hammond, Nolan Kamitaki, Katherine Tooley, J. Presumey, M. Baum, Vanessa Van Doren, G. Genovese, Samuel A. Rose, R. Handsaker, M. Daly, M. Carroll, B. Stevens, S. Mccarroll   +16 more
semanticscholar   +1 more source

Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics

Pharmacological Reviews, 2021
The complement system was discovered at the end of the 19th century as a heat-labile plasma component that “complemented” the antibodies in killing microbes, hence the name “complement.” Complement is also part of the innate immune system, protecting the
P. Garred, A. Tenner, T. Mollnes
semanticscholar   +1 more source

Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial

Trials, 2022
Background Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity.
Mieke van Schaik, Eline J. Arends, Darius Soonawala, Ellen van Ommen, Karina de Leeuw, Maarten Limper, Pieter van Paassen, Tom W. J. Huizinga, René E. M. Toes, Cees van Kooten, Joris I. Rotmans, Ton J. Rabelink, Y. K. Onno Teng   +12 more
doaj   +1 more source

Commensurability classes of 2-bridge knot complements [PDF]

Algebr. Geom. Topol. 8 (2008) 1031-1057, 2006
We show that a hyperbolic 2-bridge knot complement is the unique knot complement in its commensurability class. We also discuss constructions of commensurable hyperbolic knot complements and put forth a conjecture on the number of hyperbolic knot complements in a commensurability class.
arxiv   +1 more source

TIGIT-positive circulating follicular helper T cells display robust B-cell help functions: potential role in sickle cell alloimmunization

Haematologica, 2015
T follicular helper cells are the main CD4+ T cells specialized in supporting B-cell responses, but their role in driving transfusion-associated alloimmunization is not fully characterized.
Emmanuelle Godefroy, Hui Zhong, Petra Pham, David Friedman, Karina Yazdanbakhsh   +4 more
doaj   +1 more source

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

mBio, 2018
The complement system is a critical part of host defense to many bacterial, viral, and fungal infections. It works alongside pattern recognition receptors to stimulate host defense systems in advance of activation of the adaptive immune response. In this
Lisa E. Gralinski, T. Sheahan, T. Morrison, Vineet D. Menachery, Kara L. Jensen, S. Leist, A. Whitmore, M. Heise, R. Baric   +8 more
semanticscholar   +1 more source

Learning to Complement Humans [PDF]

International Joint Conference on Artificial Intelligence, 2020
A rising vision for AI in the open world centers on the development of systems that can complement humans for perceptual, diagnostic, and reasoning tasks.
Bryan Wilder, E. Horvitz, Ece Kamar
semanticscholar   +1 more source

Pathogenic Leptospira Secreted Proteases Target the Membrane Attack Complex: A Potential Role for Thermolysin in Complement Inhibition

Frontiers in Microbiology, 2017
Leptospirosis is a zoonosis caused by spirochetes from the genus Leptospira. This disease is common in tropical and subtropical areas, constituting a serious public health problem.
Thais A. Amamura, Tatiana R. Fraga, Sílvio A. Vasconcellos, Angela S. Barbosa, Lourdes Isaac   +4 more
doaj   +1 more source