Results 51 to 60 of about 1,441,098 (322)

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

Nature Communications, 2017
BCATs catabolize leucine and other BCAAs. Here the authors show that BCAA metabolism affects the broken Krebs cycle, reprogramming macrophages to be less proinflammatory, and show that BCAT1 inhibitor ERG240 can treat arthritis in mice and ...
Adonia E. Papathanassiu, Jeong-Hun Ko, Martha Imprialou, Marta Bagnati, Prashant K. Srivastava, Hong A. Vu, Danilo Cucchi, Stephen P. McAdoo, Elitsa A. Ananieva, Claudio Mauro, Jacques Behmoaras   +10 more
doaj   +1 more source

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
doaj   +1 more source

Murine Factor H Co-Produced in Yeast With Protein Disulfide Isomerase Ameliorated C3 Dysregulation in Factor H-Deficient Mice

Frontiers in Immunology, 2021
Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration.
Heather Kerr, Heather Kerr, Andrew P. Herbert, Elisavet Makou, Dariusz Abramczyk, Talat H. Malik, Hannah Lomax-Browne, Yi Yang, Yi Yang, Isabel Y. Pappworth, Isabel Y. Pappworth, Harriet Denton, Harriet Denton, Anna Richards, Kevin J. Marchbank, Kevin J. Marchbank, Matthew C. Pickering, Paul N. Barlow, Paul N. Barlow   +18 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Effect of different noise reduction techniques and template matching parameters on markerless tumor tracking using dual‐energy imaging

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose To evaluate the impact of various noise reduction algorithms and template matching parameters on the accuracy of markerless tumor tracking (MTT) using dual‐energy (DE) imaging. Methods A Varian TrueBeam linear accelerator was used to acquire a series of alternating 60 and 120 kVp images (over a 180° arc) using fast kV switching, on ...
Mandeep Kaur, Peter Wagstaff, Hassan Mostafavi, Mathias Lehmann, Daniel Morf, Liangjia Zhu, Hyejoo Kang, Michal Walczak, Matthew M. Harkenrider, John C. Roeske   +9 more
wiley   +1 more source

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Frontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider, Mihály Józsi, Mihály Józsi   +7 more
doaj   +1 more source

Commensurability classes containing three knot complements [PDF]

Algebr. Geom. Topol. 10 (2010) 663-677, 2009
This paper exhibits an infinite family of hyperbolic knot complements that have three knot complements in their respective commensurability classes.
arxiv   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report

Lupus Science and Medicine
Objective Combination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking.
Tineke Kraaij, Cees van Kooten, Y K Onno Teng, Tom Huizinga, Eline J Arends, Robbert J Goekoop, Ton Rabelink, Mieke van Schaik, Marjolein J A L Wetzels, Stéphanie H Verbruggen, Sandra W van der Kooij, Sylvia W A Kamerling   +11 more
doaj   +1 more source

Nephritic Factors: An Overview of Classification, Diagnostic Tools and Clinical Associations

Frontiers in Immunology, 2019
Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation.
Fernando Corvillo, Fernando Corvillo, Marcin Okrój, Pilar Nozal, Pilar Nozal, Pilar Nozal, Marta Melgosa, Marta Melgosa, Pilar Sánchez-Corral, Pilar Sánchez-Corral, Margarita López-Trascasa, Margarita López-Trascasa   +11 more
doaj   +1 more source