Results 31 to 40 of about 1,135,361 (222)

Complement component C3 binds to activated normal platelets without preceding proteolytic activation and promotes binding to complement receptor 1

, 2010
It has been reported that complement is activated on the surface of activated platelets, despite the presence of multiple regulators of complement activation. To reinvestigate the mechanisms by which activated platelets bind to complement components, the
Nilsson Ekdahl, Kristina,, Lambris, John D., Hamad, Osama A.,, Hamad, Osama, Nilsson, Per H., Nilsson, Bo,, Hamad, Osama A., Nilsson, Per H.,, Ekdahl, Kristina N.,, Ekdahl, Kristina N., Wouters, Diana, Nilsson, Bo, Lambris, John   +12 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Structural and computational enzymology: bringing experiments and computations together [PDF]

, 2012
In this introductory chapter, we present how the experimental and computational strategies in enzyme research are developed and how they complement each other to provide better insights for understanding enzyme structures and ...
Christo Christov, Christov, Christo, Tatyana Karabencheva, Karabencheva-Christova, Tatyana   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis. [PDF]

, 2018
BACKGROUND:Anti-human leukocyte antigen donor-specific antibodies (anti-HLA DSAs) are recognized as a major barrier to patients' access to organ transplantation and the major cause of graft failure.
Tyan, Dolly B, Kobashigawa, Jon, Mohammad Hassan Murad (5242784), Reed, E. F., Hidalgo, Luis G, Hidalgo, Luis G., Montgomery, R. A., Reed, Elaine F., Aubert, Olivier, Carmen Lefaucheur (5285783), Bouquegneau, Antoine, Loheac, C., Denis Glotz, Jacqueline O’Leary, Zeevi, Adriana, Taupin, J. L., Caner Süsal (5285804), Loupy, Alexandre, Annette M. Jackson (5285801), Stephan Schaub (5285795), Tyan, Dolly B., Luis G Hidalgo, Kobashigawa, J., Camilo Ulloa, Alexandre Loupy, Christophe Legendre (117048), Christophe Legendre, Yassine Bouatou (4910083), Jean–Philippe Empana, Ulloa, Camilo, Aubert, O., Tyan, Dolly, Süsal, Caner, Empana, Jean–Philippe, Bouatou, Y., Luis G. Hidalgo (127168), E Steve Woodle, Charlotte Loheac (5285786), Xavier Jouven, Taupin, Jean Luc, Robert A. Montgomery (534211), O’Leary, J., Robert A Montgomery, Woodle, E. S., Denis Viglietti, Dolly B Tyan, Empana, Jean Philippe, Viglietti, D., Reed, Elaine F, Ron Shapiro, Zeevi, A., Empana, J. P., Woodle, E Steve, Annette M. Jackson, E. Steve Woodle (4591483), Hassan Murad, Mohammad, Charlotte Loheac, Jacqueline O'Leary, Glotz, D., Schaub, Stephan, Elaine F Reed, Jackson, Annette M, Patricia Jabre (2814109), John J Friedewald, Denis Viglietti (4164640), Stephan Schaub, Ron Shapiro (658056), Shapiro, Ron, Jackson, Annette, Jean–Luc Taupin (5285777), Lefaucheur, Carmen, Schaub, S., Montgomery, Robert A., Jacqueline O’Leary (5285774), Bouatou, Yassine, Luis G. Hidalgo, Shapiro, R., Antoine Bouquegneau (5285792), Elaine F. Reed, Woodle, E. Steve, Jon Kobashigawa (5285789), Xavier Jouven (272686), Jouven, Xavier, Jean–Luc Taupin, Hidalgo, Luis, Antoine Bouquegneau, Friedewald, John J, Hidalgo, L. G., Robert A. Montgomery, Jackson, A. M., Süsal, C., Caner Süsal, Patricia Jabre, Adriana Zeevi, Denis Glotz (5285798), Tyan, D. B., Montgomery, Robert, John J. Friedewald, Loupy, A., Viglietti, Denis, Olivier Aubert, Montgomery, Robert A, Carmen Lefaucheur, Legendre, C., Camilo Ulloa (5285768), Hassan Murad, M., Elaine F. Reed (188438), Olivier Aubert (5285807), Jean-Luc Taupin, Ulloa, C., O’Leary, Jacqueline, E. Steve Woodle, Empana, Jean‐philippe, Jouven, X., Dolly B. Tyan (5285771), Glotz, Denis, Jabre, P., Dolly B. Tyan, Mohammad Hassan Murad, Alexandre Loupy (369511), Loheac, Charlotte, Jean-Philippe Empana, Reed, Elaine, Taupin, Jean–Luc, Yassine Bouatou, John J. Friedewald (3186159), Lefaucheur, C., Jon Kobashigawa, Adriana Zeevi (355603), Jean–Philippe Empana (5285780), Annette M Jackson, Legendre, Christophe, Friedewald, John J., Friedewald, John, Jabre, Patricia, Friedewald, J. J., Jackson, Annette M., Murad, Mohammad Hassan   +137 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture [PDF]

, 2004
Platelet-activating factor and nitric oxide may be involved in the initiation of human labour as inflammatory mediators. The aim of this study was to test whether platelet-activating factor and lipopolysaccharide were able to induce nitric oxide synthase
Damian J Murphy, Dunmore, Simon J., Murphy Damian J, Carson Ray J, Rodrigo, Nalinda, Seyffarth Gunter, Nelson, Paul N., Dunmore Simon J, Simon J Dunmore, Nalinda Rodrigo, Carson, Ray J., Seyffarth, Gunther, Rodrigo Nalinda, Paul N Nelson, Murphy, Damian J., Nelson Paul N, Gunter Seyffarth, Ray J Carson   +17 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source