Results 21 to 30 of about 48,485 (265)
Frontiers in Immunology, 2021 As an intermediate substance of the tricarboxylic acid cycle and a precursor substance of glutamic acid synthesis, the effect of alpha-ketoglutarate on growth and protein synthesis has been extensively studied.
Di Wu +6 more
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Platelets (thrombocytes): The other recognized functions [PDF]
Hospital Pharmacology, 2016 Introduction: Platelets are smallest blood cells of discoid or round shape and are cytoplasmic fragments of megakaryocytes. Platelets consist of 3 types of granules: alpha granules, dense granules and lysosomes.
Nikolić Ljubinka I. +3 more
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Smallpox Inhibitor of Complement Enzymes (SPICE): Regulation of Complement Activation on Cells and Mechanism of Its Cellular Attachment [PDF]
The Journal of Immunology, 2008 Abstract Despite eradication of smallpox three decades ago, public health concerns remain due to its potential use as a bioterrorist weapon. Smallpox and other orthopoxviruses express virulence factors that inhibit the host’s complement system.
M Kathryn, Liszewski +5 more
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Consecutive enzyme cascades: complement activation at the cell surface triggers increased tissue factor activity [PDF]
Blood, 1990 Abstract Complement activation at the cell surface initiates cell damage through a series of reactions occurring at the cell membrane and, after assembly of the terminal membrane attack complex, produces leakage of cytoplasmic contents from the cell.
S D, Carson, D R, Johnson
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Lectin Pathway Enzyme MASP-2 and Downstream Complement Activation in COVID-19
Journal of Innate Immunity, 2022 Mannose-binding lectin-associated serine protease 2 (MASP-2) is the main activator of the lectin complement pathway and has been suggested to be involved in the pathophysiology of coronavirus disease 2019 (COVID-19). To study a possible association between MASP-2 and COVID-19, we aimed at developing a sensitive and reliable MASP-2 ELISA.
Götz, Maximilian Peter +8 more
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Smallpox Inhibitor of Complement Enzymes (SPICE): Dissecting Functional Sites and Abrogating Activity [PDF]
The Journal of Immunology, 2009 Abstract Although smallpox was eradicated as a global illness more than 30 years ago, variola virus and other related pathogenic poxviruses, such as monkeypox, remain potential bioterrorist weapons or could re-emerge as natural infections. Poxviruses express virulence factors that down-modulate the host’s immune system.
M Kathryn, Liszewski +5 more
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Complement activation and regulation in preeclampsia and hemolysis, elevated liver enzymes, and low platelet count syndrome [PDF]
American Journal of Obstetrics and Gynecology, 2022 The complement system is critical to human health owing to its central role in host defense and innate immunity. During pregnancy, the complement system must be appropriately regulated to allow for immunologic tolerance to the developing fetus and placenta.
Richard M, Burwick, Bruce B, Feinberg
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, 2023 Terminal complement complex (TCC) deposition was identified in human degenerated discs. To clarify the role of terminal complement activation in disc degeneration (DD), we investigated respective activating mechanisms and cellular effects in annulus ...
Amelie Kuhn +6 more
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Non-enzymic activation of the covalent binding reaction of the complement protein C3 [PDF]
Biochemical Journal, 1983 The covalent binding of [3H]glycerol to C3 by the transfer of the acyl group of the internal thioester of C3 to the hydroxy group of glycerol can be activated either proteolytically by trypsin or by various chaotropes and denaturants. The activation of binding by trypsin or KBr showed similar dependence on the concentration of glycerol, indicating a ...
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, 2022 As part of the innate immune system, the complement system plays a key role in defense against pathogens and in host cell homeostasis. This enzymatic cascade is rapidly triggered in the presence of activating surfaces.
Anna Duval (12403186) +4 more
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