Results 91 to 100 of about 4,342,004 (341)

Complement Activation and Organ Damage After Trauma—Differential Immune Response Based on Surgical Treatment Strategy

Frontiers in Immunology, 2020
Background: The complement system is part of the innate immunity, is activated immediately after trauma and is associated with adult respiratory distress syndrome, acute lung injury, multiple organ failure, and with death of multiply injured patients ...
Ina Lackner, Birte Weber, Meike Baur, Giorgio Fois, Florian Gebhard, Roman Pfeifer, Paolo Cinelli, Sascha Halvachizadeh, Miriam Lipiski, Nikola Cesarovic, Hubert Schrezenmeier, Hubert Schrezenmeier, Markus Huber-Lang, Hans-Christoph Pape, Miriam Kalbitz   +14 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Complement activation in wasp venom-induced acute kidney injury

Renal Failure
Previous studies have highlighted the significant role of complement activation in kidney injuries induced by rhabdomyolysis, intravascular hemolysis, sepsis, and ischemia-reperfusion.
Rui Cheng, Liang Xu, Jianhua Gong, Fanglin Yu, Ying Lv, Hai Yuan, Fengqi Hu   +6 more
doaj   +1 more source

Prolonged complement activation in mice

Kidney International, 1978
Because antibody responses to the alternative complement pathway activator, cobra venom factor, are T-dependent and B mice therefore do not develop resistance to its action, it was possible to examine whether renal injury occurs under circumstances of protracted third-phase alternative pathway activation.
Simpson, I.j., Moran, J., Evans, D.j., Peters, D.k.   +3 more
openaire   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications

Frontiers in Immunology, 2018
Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies.
Francesco Tedesco, Maria Orietta Borghi, Maria Orietta Borghi, Maria Gerosa, Cecilia Beatrice Chighizola, Cecilia Beatrice Chighizola, Paolo Macor, Paola Adele Lonati, Alessandro Gulino, Beatrice Belmonte, Pier Luigi Meroni   +10 more
doaj   +1 more source

P-MAPA, a Fungi-Derived Immunomodulatory Compound, Induces a Proinflammatory Response in a Human Whole Blood Model

Mediators of Inflammation, 2020
P-MAPA is a complex compound, derived from Aspergillus oryzae cultures, that has shown immunomodulatory properties in infection and cancer animal models.
Mariana Torrente Gonçalves, Carla Cristina Squaiella-Baptistão, Giselle Pidde, Priscila Hess Lopes, Iseu da Silva Nunes, Denise V. Tambourgi   +5 more
doaj   +1 more source

Cell-bound complement activation products in SLE

Lupus Science and Medicine, 2017
Diagnosis of SLE is based on clinical manifestations and laboratory findings. Timely diagnosis and treatment are important to control disease activity and prevent organ damage.
R. Ramsey‐Goldman, Jian Li, T. Dervieux, R. Alexander   +3 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Complement Activation by Trichophyton rubrum

Journal of Investigative Dermatology, 1983
The role of complement in infections by dermatophytes is unknown. Therefore we evaluated the ability of the dermatophyte Trichophyton rubrum to activate complement in vitro. Aliquots of human plasma that had been incubated with T. rubrum were examined for evidence of complement activation.
Swan, James W., Dahl, Mark V., Coppo, Patricia A., Hammerschmidt, Dale E.   +3 more
openaire   +2 more sources