Results 191 to 200 of about 275,985 (253)

DNA Flap‐Mediated Control of Transcription for Programmable RNA Synthesis

Angewandte Chemie International Edition, EarlyView.
Pyrimidine‐rich ssDNA flaps on the T7 promoter inhibit T7 RNA polymerase (T7RP) transcription. Leveraging this pyrimidine bias, we developed DNAzyme‐ and MNAzyme‐mediated flap promoter induced transcription control (D‐FIT and M‐FIT) systems. These platforms enable regulated transcription and sequence‐specific detection, highlighting the programmable ...
Eun Sung Lee, Jisu Woo, Seokjoon Kim, Seok Hyeon Kim, Gun Haeng Lee, Ki Soo Park   +5 more
wiley   +1 more source

Therapeutic Potential of C1-Inhibitor in Vascular Diseases and Beyond. [PDF]

Arterioscler Thromb Vasc Biol
Sundler Björkman L, Eswaran H, Grover SP.   +2 more
europepmc   +1 more source

The power of a pill: Ekterly (Sebetralstat): first oral on-demand therapy for hereditary angioedema-a paradigm shift in treatment. [PDF]

Ann Med Surg (Lond)
Bukhari SMR, Rashidi R.
europepmc   +1 more source

Long lasting complement neutralisation by RAY121, an engineered anti-C1s antibody with C1q displacement function. [PDF]

EBioMedicine
Ho AWS, Fukuzawa T, Koga H, Ohmine K, Kawauchi H, Muraoka M, Ikuta Y, Gupta G, Okuda M, Onami I, Ayabe M, Takeiri A, Konishi H, Sugawara Y, Usami S, Ito E, Shibahara N, Ozeki K, Wada Y, Hirako A, Takahashi N, Sampei Z, Haraya K, Murao N, Fujii T, Torizawa T, Shimada H, Igawa T.   +27 more
europepmc   +1 more source

In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients. [PDF]

Sci Rep
Kiszel P, Miklós J, Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z.   +5 more
europepmc   +1 more source

Oxygen-dependent modulation of the human complement system during acute normobaric hypoxia: a translational plasma proteomics study. [PDF]

Clin Exp Med
Lang A, Pang TY, Piel S, Oehler D, Zweck E, Shahrjerdi K, Okkasian M, Georgy J, Reinders Y, Duplessis AJ, Tank J, Jordan J, Pfeiler S, Sickmann A, Kelm M, Jung C, Gerdes N.   +16 more
europepmc   +1 more source

Complement activation in immunological neurological disorders: mechanisms and therapeutic strategies. [PDF]

Front Neurol
Chen JY, Sanghani N, Palmer K, Li Y, Lin F, Abbatemarco JR.   +5 more
europepmc   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, EarlyView.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

Hereditary Angioedema With Normal C1 Esterase Inhibitor: A Case of a Late Diagnosis in a 48-Year-Old Male. [PDF]

Cureus
Elazar N, Kesselman MM.
europepmc   +1 more source

New craniodental materials of Falcarius utahensis (Theropoda: Therizinosauria) reveal patterns of intraspecific variation and cranial evolution in early coelurosaurians

The Anatomical Record, EarlyView.
Abstract Despite documented ecomorphological shifts toward an herbivorous diet in several coelurosaurian lineages, the evolutionary tempo and mode of these changes remain poorly understood, hampered by sparse cranial materials for early representatives of major clades. This is particularly true for Therizinosauria, with representative crania best known
William J. Freimuth, Lindsay E. Zanno
wiley   +1 more source