Results 1 to 10 of about 65,236 (304)

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +6 more sources

Complement Regulatory Protein C1 Inhibitor Binds to Selectins and Interferes with Endothelial-Leukocyte Adhesion [PDF]

The Journal of Immunology, 2003
AbstractC1 inhibitor (C1INH), a member of the serine proteinase inhibitor (serpin) family, is an inhibitor of proteases in the complement system, the contact system of kinin generation, and the intrinsic coagulation pathway. It is the most heavily glycosylated plasma protein, containing 13 definitively identified glycosylation sites as well as an ...
Shenghe Cai, Alvin E. Davis
semanticscholar   +5 more sources

Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis.

The Tohoku Journal of Experimental Medicine, 1988
By using single radial immunodiffusion we measured the plasma levels of four complement modulating proteins, i.e., C1 inhibitor, C4-binding protein, factor H and factor I in 19 psoriatic patients in comparison with those of healthy controls. Except for C1 inhibitor which was only marginally elevated, they were found to be significantly increased in ...
Kyoko Ohkohchi, Wakio Torinuki, Hachiro Tagami   +2 more
semanticscholar   +5 more sources

Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. [PDF]

PLoS Pathogens, 2016
Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade innate immune defenses, notably the complement system.
Brandon L Garcia, Hui Zhi, Beau Wager, Magnus Höök, Jon T Skare   +4 more
doaj   +7 more sources

Serum concentrations of C reactive protein, α₁antitrypsin, and complement (C3, C4, C1 esterase inhibitor) before and during the Vuelta a Espańa [PDF]

British Journal of Sports Medicine, 2006
Objectives:To determine serum concentrations of proinflammatory (C reactive protein, complement C3 and C4) and anti-inflammatory (α1antitrypsin, C1 esterase inhibitor (C1-INH)) acute phase proteins in elite cyclists before and during a three week cycle tour.Methods:Seventeen professional cyclists participating in the Vuelta a Espańa volunteered for the
Stuart Semple, Lucille L. Smith, Andrew J. McKune, Jesús Hoyos, B. B. N. Mokgethwa, Alejandro F. San Juan, Alejandro Lucı́a, A A Wadee   +7 more
openalex   +6 more sources

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom   +14 more
doaj   +2 more sources

Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components. [PDF]

PLoS ONE, 2013
Spirochetes belonging to the Borrelia (B.) burgdorferi sensu lato complex differ in their resistance to complement-mediated killing, particularly in regard to human serum.
Jasmin Schwab, Claudia Hammerschmidt, Dania Richter, Christine Skerka, Franz-Rainer Matuschka, Reinhard Wallich, Peter F Zipfel, Peter Kraiczy   +7 more
doaj   +17 more sources

Anaesthesia Management of a Case with Hereditary Angioedema for Whom Tracheal Dilatation was Planned [PDF]

Turkish Journal of Anaesthesiology and Reanimation
Hereditary angioedema (HAE) causes recurrent angioedema attacks in the oropharynx, larynx, face, and other regions due to bradykinin overproduction as a result of C1 esterase inhibitor deficiency.
Muharrem Uçar, Mukadder Şanlı, Sezai Aktürk, İlham Gülçek, Feray Akgül Erdil   +4 more
doaj   +2 more sources

Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor

Experimental Neurology, 1999
Complement activation products C1q, C4c/d, and C3c/d in amyloid plaques in Alzheimer's disease probably result from direct binding and activation of C1 by amyloid beta peptides. RT-PCR and in situ hybridization studies have shown that several complement factors are produced in the brain parenchyma.
Robert Veerhuis, I. Janssen, Corline J.A. De Groot, F. L. Van Muiswinkel, C. Erik Hack, Piet Eikelenboom   +5 more
openalex   +5 more sources

Endothelial Cells Cultured from Human Brain Microvessels Produce Complement Proteins Factor H, Factor B, C1 Inhibitor, and C4

Immunobiology, 1998
The inflammatory mediators, cytokines and complement proteins are believed to regulate the sequential events during the development of lesions secondary to ischaemia and reperfusion. The endothelial cell monolayer of the brain microvasculature is the critical interface between the blood-borne mediators and brain tissue.
Mónika Vastag, Judit Skopál, Judit Krámer, Krasimir Kolev, Zoltán Vokó, E Csonka, Raymund Machovich, Zsolt Nagy   +7 more
openalex   +3 more sources