Results 1 to 10 of about 49,543 (282)

Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis. [PDF]

PLoS Neglected Tropical Diseases, 2010
The spirochete Borrelia recurrentis is the causal agent of louse-borne relapsing fever and is transmitted to humans by the infected body louse Pediculus humanus. We have recently demonstrated that the B.
Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J Cutler, Markus M Simon, Reinhard Wallich   +5 more
doaj   +6 more sources

Serum concentrations of C reactive protein, α₁antitrypsin, and complement (C3, C4, C1 esterase inhibitor) before and during the Vuelta a Espańa [PDF]

British Journal of Sports Medicine, 2006
Objectives:To determine serum concentrations of proinflammatory (C reactive protein, complement C3 and C4) and anti-inflammatory (α1antitrypsin, C1 esterase inhibitor (C1-INH)) acute phase proteins in elite cyclists before and during a three week cycle tour.Methods:Seventeen professional cyclists participating in the Vuelta a Espańa volunteered for the
Stuart Semple, Lucille L. Smith, Andrew J. McKune, Jesús Hoyos, B. B. N. Mokgethwa, Alejandro F. San Juan, Alejandro Lucı́a, A A Wadee   +7 more
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Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor

Experimental Neurology, 1999
Complement activation products C1q, C4c/d, and C3c/d in amyloid plaques in Alzheimer's disease probably result from direct binding and activation of C1 by amyloid beta peptides. RT-PCR and in situ hybridization studies have shown that several complement factors are produced in the brain parenchyma.
Robert Veerhuis, I. Janssen, Corline J.A. De Groot, F. L. Van Muiswinkel, C. Erik Hack, Piet Eikelenboom   +5 more
openalex   +5 more sources

An anti-endotoxin peptide that generates from the amino-terminal domain of complement regulatory protein C1 inhibitor

Biochemical and Biophysical Research Communications, 2007
C1 inhibitor (C1INH), a complement regulatory protein, prevents endotoxin shock via a direct interaction of the amino-terminal domain with gram-negative bacterial lipopolysaccharide (LPS). Importantly, the cleaved, inactive C1INH still is an anti-endotoxin effector indicating the anti-endotoxin peptide that generates from the amino-terminal domain of ...
Haimou Zhang, Jinan Li, Robert A. Barrington, Gang Liang, Gangjian Qin, Dong-xu Liu   +5 more
openalex   +3 more sources

Increased plasma concentrations of complement modulating proteins (C1 inhibitor, C4-binding protein, factor H and factor I) in psoriasis.

The Tohoku Journal of Experimental Medicine, 1988
By using single radial immunodiffusion we measured the plasma levels of four complement modulating proteins, i.e., C1 inhibitor, C4-binding protein, factor H and factor I in 19 psoriatic patients in comparison with those of healthy controls. Except for C1 inhibitor which was only marginally elevated, they were found to be significantly increased in ...
Kyoko Ohkohchi, Wakio Torinuki, Hachiro Tagami   +2 more
openalex   +4 more sources

Complement Regulatory Protein C1 Inhibitor Binds to Selectins and Interferes with Endothelial-Leukocyte Adhesion [PDF]

The Journal of Immunology, 2003
AbstractC1 inhibitor (C1INH), a member of the serine proteinase inhibitor (serpin) family, is an inhibitor of proteases in the complement system, the contact system of kinin generation, and the intrinsic coagulation pathway. It is the most heavily glycosylated plasma protein, containing 13 definitively identified glycosylation sites as well as an ...
Shenghe Cai, Alvin E. Davis
openalex   +3 more sources

Endothelial Cells Cultured from Human Brain Microvessels Produce Complement Proteins Factor H, Factor B, C1 Inhibitor, and C4

Immunobiology, 1998
The inflammatory mediators, cytokines and complement proteins are believed to regulate the sequential events during the development of lesions secondary to ischaemia and reperfusion. The endothelial cell monolayer of the brain microvasculature is the critical interface between the blood-borne mediators and brain tissue.
Mónika Vastag, Judit Skopál, Judit Krámer, Krasimir Kolev, Zoltán Vokó, E Csonka, Raymund Machovich, Zsolt Nagy   +7 more
openalex   +3 more sources

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundDysregulated complement activation, increased protein citrullination, and production of autoantibodies against citrullinated proteins are hallmarks of rheumatoid arthritis (RA).
Myriam Martin, Sara C. Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M. Vogt, Ewa Bielecka, Jan Potempa, Jan Potempa, Jan J. Enghild, Bo Nilsson, Kristina N. Ekdahl, Kristina N. Ekdahl, Meliha C. Kapetanovic, Anna M. Blom   +14 more
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Recombinant human C1 esterase inhibitor for hereditary angioedema attacks: A European registry

World Allergy Organization Journal, 2021
Background: Hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling attacks. A European treatment registry was established to review the adverse event profile and efficacy of recombinant ...
Anna Valerieva, Maria T. Staevska, Vesna Grivcheva-Panovska, Milos Jesenak, Kinga Viktória Kőhalmi, Katarina Hrubiskova, Andrea Zanichelli, Luca Bellizzi, Anurag Relan, Roman Hakl, Henriette Farkas   +10 more
doaj   +1 more source

Clinical profile and treatment outcomes in patients with hereditary angioedema with normal C1 esterase inhibitor

World Allergy Organization Journal, 2022
Background: Hereditary angioedema (HAE) is often caused by low serum levels or functional deficiency in C1 inhibitor (C1-INH); however, in some cases, C1-INH serum level and function are measured as normal (HAE-nl-C1INH).
Douglas H. Jones, MD, Priya Bansal, MD, Jonathan A. Bernstein, MD, Shahnaz Fatteh, MD, Joseph Harper, PharmD, F. Ida Hsu, MD, Maeve O’Connor, MD, Nami Park, PharmD, Daniel Suez, MD   +8 more
doaj   +1 more source