Results 111 to 120 of about 65,236 (304)

A Multicenter Validation of a Fully Automated Chemiluminescence Immunoassay for Plasma Elafin in Psoriasis Diagnosis and Severity Assessment

Advanced Science, EarlyView.
The fully automated CLIA demonstrates high sensitivity and specificity for plasma Elafin, achieving 88% diagnostic accuracy and an AUC of 0.92 for psoriasis detection in a multicenter cohort. The assay reliably distinguishes psoriasis from other dermatoses, objectively stratifies disease severity, and allows longitudinal monitoring, supporting its ...
Jingkun Yi, Meng Xu, Ling Han, Zhining Dong, Ruimin Liu, Xiaomei Zhang, Di Hu, Chuanjian Lu, Xiaobo Yu   +8 more
wiley   +1 more source

BIOINFORMATIC ANALYSIS OF SINGLE NUCLEOTIDE VARIANTS IN THE F12 GENE ASSOCIATED WITH HEREDITARY ANGIOEDEMA

Медицинская иммунология, 2019
Hereditary angioedema (HAE) is a genetically determined disorder classified as a primary immunodeficiency involving complement system dysfunction. In most patients, the disease is characterized by a deficiency of C1 inhibitor (type I HAE) or impaired ...
Anna Sedykh, Yulia Ostankova, Alexandr Schemelev, Areg Totolian   +3 more
doaj   +1 more source

Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities [PDF]

, 2018
Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of death and disability worldwide. As such, new therapies are required to limit myocardial infarct (MI) size, prevent adverse left ventricular (LV) remodeling ...
Cabrera-Fuentes, HA, Crespo-Avilan, GE, Hausenloy, DJ, Hernández-Reséndiz, S, Kwek, X-Y, Mukhametshina, RT, Ong, S-B   +6 more
core   +1 more source

Protein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of PtdSer‐positive senescent and altered erythrocytes such as erythrocyte ghosts (eryghosts ...
Claire Auditeau, Aurélie Fricot, Raphaël Gauthier, Abdoulaye Sissoko, Zeynep Cacan, Céline Gounou, Laure Joseph, Sandra Manceau, Slimane Allali, Michael Dussiot, Mickael Marin, Alexis Lavergne, Mariem Khamari, Sophie Moog, Elsa Bianchini, Laetitia Claer, Sandrine Laurance, Valentine Brousse, Sébastien Eymieux, Philippe Roingeard, Pascal Amireault, Thiago Trovati Maciel, Alain Brisson, Pierre Buffet, François Saller, Delphine Borgel, Camille Roussel   +26 more
wiley   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Revisiting the monocrotaline‐treated rat as a model of inflammatory lung disease: COVID‐19 and future pandemic threats?

Animal Models and Experimental Medicine, EarlyView.
In this review, the pathological, molecular, and cellular changes observed in the COVID‐19 lung are compared to those in the laboratory rat treated with monocrotaline (MCT). Similarities that reflect common changes associated with inflammation and endothelial cell dysfunction are observed in both states, leading to a lung pathology characterized by ...
Luke P. Kris, Dani‐Louise Dixon, Shailesh Bihari, Jillian M. Carr   +3 more
wiley   +1 more source

A Review of Randomized Controlled Trials of Hereditary Angioedema Long-Term Prophylaxis with C1 Inhibitor Replacement Therapy: Alleviation of Disease Symptoms Is Achievable

Journal of Asthma and Allergy, 2023
Hilary J Longhurst,1,* Anna Valerieva2,* 1Department of Medicine, University of Auckland and Department of Immunology, Auckland City Hospital, Auckland, New Zealand; 2Department of Allergology, Medical University of Sofia, Sofia, Bulgaria&ast ...
Longhurst HJ, Valerieva A
doaj  

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection. [PDF]

, 2020
Single-cell transcriptomics was used to profile cells of the normal murine middle ear. Clustering analysis of 6770 transcriptomes identified 17 cell clusters corresponding to distinct cell types: five epithelial, three stromal, three lymphocyte, two ...
Draf, Clara, Fisch, Kathleen M, Kurabi, Arwa, Nasamran, Chanond A, Pak, Kwang, Ryan, Allen F, Webster, Nicholas   +6 more
core  

Nucleic Acid‐Based Molecular Machines for Biological Applications

Advanced NanoBiomed Research, EarlyView.
Molecular machines are devices assembled from molecules with specific functions. In this review, the development of DNA nanostructures, which are then assembled into molecular machines, is summarized. Their classification and biological applications, such as biosensing, targeted therapy, and molecular circuits are introduced.
Yirong Guo, Xiaolei Zuo, Fangfei Yin
wiley   +1 more source

Synthesis and Application of Bioactive N‐Functionalized Aziridines

Angewandte Chemie, EarlyView.
This review discusses modern synthetic methods for the preparation of aziridine‐containing small molecules, including biocatalytic, electrocatalytic, and photocatalytic strategies. We highlight the compatibility of various synthetic methods with control of the exocyclic N‐substituent.
Hao Tan, Samya Samanta, Nan Qiu, Alexander Adibekian, David C. Powers   +4 more
wiley   +1 more source