Results 101 to 110 of about 4,257,255 (225)
Érzékenyített módszer kidolgozása C1-inhibitor analízisére
, 2014 A C1-inhibitor fő szabályozója a komplement-, kinin-, koagulációs- és fibrinolitikus rendszereknek. A funkcióképes C1-inhibitor az aktív enzimekkel reagálva stabil kovalens komplexeket képez, ugyanakkor a natív és komplex forma mellett hasi ...Madarasi, Irén Anikócore Identification and functional characterisation of Complement Regulator Acquiring Surface Protein-1 of serum resistant Borrelia garinii OspA serotype 4 [PDF]
, 2010 Background: B. burgdorferi sensu lato (sl) is the etiological agent of Lyme borreliosis in humans. Spirochetes have adapted themselves to the human immune system in many distinct ways.Peter F. Zipfel, Dam, A.P. van, Schuijt, Tim J., Kraiczy, Peter, Nathalie D. van Burgel, Nathalie D. van Burgel, van Dam, Alje P., van Burgel Nathalie D, Burgel, N.D. van, Burgel, Nathalie D. van, Schuijt Tim J, Tim J. Schuijt, Kraiczy Peter, Schuijt, T.J., van Dam Alje P, Zipfel Peter F, Kraiczy, P., Zipfel, Peter F., Alje P. van Dam, Peter Kraiczy, Zipfel, P.F., Dam, Alje P. van, van Burgel, Nathalie D. +22 morecore +1 more sourceCarbohydrate‐Mediated Cellular Uptake of Boronic Acid Hybrids In Cellulo and Insulin‐Deficient Zebrafish: Live Imaging and Application of Multiphoton FLIM
Advanced Science, EarlyView.Boronic acid‐based fluorescent hybrids have been used as part of a versatile platform for real‐time metabolic bioimaging across cellular and organismal scales. Including glucose‐responsive imaging in living cells and in an insulin‐deficient vertebrate model, this work opens new opportunities for the development of precision diagnostics, metabolic ...Haobo Ge, John S. Fossey, David Gonzalez Calatayud, Stephen E. Flower, Sabrina Wang, Hanna Aitessaid, Melita Tvardauskaite, Julia Dudzic, Max Jewell, Charareh Pourzand, Stanley W. Botchway, David Gurevich, Tony D. James, Sofia I. Pascu +13 morewiley +1 more sourceAIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims
Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei +9 morewiley +1 more sourceC1 inhibitor: just a serine protease inhibitor? New and old considerations on therapeutic applications of C1 inhibitor
, 2008 C1 inhibitor is a potent anti-inflammatory protein as it is the major inhibitor of proteases of the contact and the complement systems. C1-inhibitor administration is an effective therapy in the treatment of patients with hereditary angioedema (HAE) who ...Sacha Zeerleder, Wagenaar-Bos, Ineke, Ineke Wagenaar-Bos, Marieke van Ham, Wouters, Diana, Zeerleder, Sacha, Diana Wouters, van Ham, Marieke +7 morecore +1 more sourceHAE international home therapy consensus document [PDF]
, 2010 Hereditary angioedema (C1 inhibitor deficiency, HAE) is associated with intermittent swellings which are disabling and may be fatal. Effective treatments are available and these are most useful when given early in the course of the swelling.Bowen, Tom, Craig, Timothy, Boysen, Henrik, E. Aygören Pürsün, Janet Long, Zuraw Bruce, Avner Reshef, Longhurst, Hilary J., Cicardi Marco, Bygum, Anette, Hilary J Longhurst, Bruce Zuraw, Anette Bygum, Martinez-Saguer, Inmaculada, Bork Konrad, Inmaculada Martinez-Saguer, Sofia Grigoriadou, Caballero, Teresa, Claire Bethune, I. Martinez Saguer, Reshef Avner, Martinez Saguer, Inmaculada, M. Raguet, H. J. Longhurst, J. Bjorkander, Laurence Bouillet, Levi Marcel M, Raguet Michel, Timothy Craig, Bethune Claire, T. Bowen, Michel Raguet, L. Bouillet, Marco Cicardi, Gompels Mark, Bork, Konrad, C. Bethune, Dempster, John, Huffer Ursula, Marcel M Levi, Longhurst, Hilary, Aygören-Pürsün Emel, M. Cicardi, Farkas Henriette, Henriette Farkas, Raguet, Michel, Bygum Anette, Bjorkander Janne, Levi, Marcel M, Longhurst Hilary J, Martinez-Saguer Inmaculada, Teresa Caballero, Ursula Huffer, Bouillet, Laurence, H. Farkas, Boysen Henrik, Huffer, Ursula, M. M. Levi, M. Gompels, Gompels, Mark, S. Grigoriadou, Kreuz, Wolfhart, Janne Bjorkander, A. Bygum, Craig Timothy, Longhurst, Hilary J, Farkas, Henriette, Bygum, Anette; id_orcid, Bowen Tom, Gooi Jimmy, Bouillet Laurence, Boysen, Henrik B., A. Reshef, J. Gooi, J. Dempster, Konrad Bork, Henrik Boysen, Gooi, Jimmy, Jimmy Gooi, Cicardi, Marco, T. Craig, B. Zuraw, Caballero Teresa, Bethune, Claire, U. Huffer, Levi, Marcel M., Dempster John, John Dempster, Grigoriadou Sofia, Reshef, Avner, Long Janet, H. Boysen, Grigoriadou, Sofia, Bjorkander, Janne, T. Caballero, Tom Bowen, Zuraw, Bruce, J. Long, W. Kreuz, Mark Gompels, Emel Aygören-Pürsün, Aygören-Pürsün, Emel, K. Bork, Kreuz Wolfhart, Long, Janet, Wolfhart Kreuz +105 morecore +1 more sourceReversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System
Advanced Science, EarlyView.A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu +17 morewiley +1 more sourceC1 esterase inhibitor (C1–INH) response as a supportive diagnostic criterion for patients with suspected hereditary angioedema with normal C1–INH
World Allergy Organization JournalDiagnosis of hereditary angioedema (HAE) with normal C1INH level (HAE-nl-C1INH) is based on several criteria, including either an associated genetic variant identified or family history of recurrent angioedema plus lack of high-dose antihistamine ...Andrew M. Smith, MD, Henry J. Kanarek, MD, Jeffrey Rumbyrt, MD, Yusaf Hussain, DO, Lily M. Lim, MD, Shahnaz Fatteh, MD, Heidi Memmott, PharmD, Teresa Chu, PhD, Maunish Patel, MD, Ralph Rivera, PharmD, Jay M. Kashkin, MD, Douglas H. Jones, MD +11 moredoaj +1 more sourceA Review of Randomized Controlled Trials of Hereditary Angioedema Long-Term Prophylaxis with C1 Inhibitor Replacement Therapy: Alleviation of Disease Symptoms Is Achievable
Journal of Asthma and Allergy, 2023 Hilary J Longhurst,1,* Anna Valerieva2,* 1Department of Medicine, University of Auckland and Department of Immunology, Auckland City Hospital, Auckland, New Zealand; 2Department of Allergology, Medical University of Sofia, Sofia, Bulgaria&ast ...Longhurst HJ, Valerieva Adoaj Intelligent Programmable Membrane Nanosponge for Early Virus Blocking
Advanced Science, EarlyView.A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai +17 morewiley +1 more source
