Results 181 to 190 of about 4,257,255 (225)

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

TurboID‐based proteomic profiling reveals proxitome of the IRT1 metal transporter and new insight into IRT1 endocytosis

New Phytologist, EarlyView.
Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1‐interacting proteins upon different metal regimes. Among validated candidates, the endosome‐localized NHX5 Na+ (K+)/H+ antiporter and the plasma membrane ...
Liza Pellegrin, Steven Fanara, Bertrand Fabre, Carole Pichereaux, Nathalie Leonhardt, Valérie Cotelle, Grégory Vert, Julie Neveu   +7 more
wiley   +1 more source

A Repertoire of Major Genes From Crop Wild Relatives for Breeding Disease‐Resistant Wheat, Rice, Maize, Soybean and Cotton Crops

Plant Breeding, EarlyView.
ABSTRACT Global food demand is predicted to rise anywhere from 59% to 98% by 2050 because of increasing population. However, the continued depletion of natural resources and increasing biotic and abiotic stresses will continue to pose significant threats to global food security in coming years.
Memoona Khalid, Hafiz Mamoon Rehman, Tsz‐Yan Cheung, Shakeel Ahmed, Ting Fung Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Multi‐Subunit Engineering of Photorespiratory Glycine Decarboxylase Refines Photosynthesis, Growth and Metabolic Robustness of Arabidopsis

Plant, Cell &Environment, EarlyView.
ABSTRACT Photorespiration secures oxygenic photosynthesis from metabolic constraints arising from the oxygenation reaction of Rubisco in today's oxygen‐rich atmosphere. Beyond this protective function, it is vital for primary metabolism, cellular redox balance, and stomatal regulation.
Hu Sun, Yannic C. R. Wagner, Wieke‐Marie Rosenfeldt, Rhena Schumann, Stéphanie Arrivault, Guillaume Decros, Rhiannon Page, Elizabete Carmo Silva, Tracy Lawson, Wei Huang, Alisdair R. Fernie, Hermann Bauwe, Martin Hagemann, Stefan Timm   +13 more
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

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Factor J, a human inhibitor of complement C1, is a cationic, highly glycosylated protein

Immunology Letters, 1994
Factor J (FJ) is a new inhibitor of the complement system. This work supports the fact that FJ is a cationic molecule (pI > or = 9.6 in native conditions, or pI = 8.1 in denaturing conditions) with a high sugar content (40%) that is able to interact with different lectins, suggesting a complex glycosylation.
Margarita López-Trascasa, Miguel Angel Jiménez-Clavero   +1 more
exaly   +3 more sources

An anti-endotoxin peptide that generates from the amino-terminal domain of complement regulatory protein C1 inhibitor

Biochemical and Biophysical Research Communications, 2007
C1 inhibitor (C1INH), a complement regulatory protein, prevents endotoxin shock via a direct interaction of the amino-terminal domain with gram-negative bacterial lipopolysaccharide (LPS). Importantly, the cleaved, inactive C1INH still is an anti-endotoxin effector indicating the anti-endotoxin peptide that generates from the amino-terminal domain of ...
Haimou, Zhang, Jinan, Li, Robert A, Barrington, Gang, Liang, Gangjian, Qin, Dong-Xu, Liu   +5 more
openaire   +2 more sources

Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action

Biochemical and Biophysical Research Communications, 2007
Increased expression of adhesion molecules by activated endothelium is a critical feature of vascular inflammation associated with the several diseases such as endotoxin shock and sepsis/septic shock. Our data demonstrated complement regulatory protein C1 inhibitor (C1INH) prevents endothelial cell injury.
Haimou, Zhang, Gangjian, Qin, Gang, Liang, Jinan, Li, Isaac, Chiu, Robert A, Barrington, Dongxu, Liu   +6 more
openaire   +2 more sources