Results 21 to 30 of about 65,236 (304)

Recombinant Human C1 Esterase Inhibitor for the Management of Adverse Events Related to Intravenous Immunoglobulin Infusion in Patients With Common Variable Immunodeficiency or Polyneuropathy: A Pilot Open-Label Study

Frontiers in Immunology, 2021
It has been hypothesized that low levels of C1 esterase inhibitor (C1-INH), a key inhibitor of the complement pathway, may play a role in the occurrence of adverse events (AEs) associated with intravenous immunoglobulin (IVIG) therapy.
Isaac R. Melamed, Holly Miranda, Melinda Heffron, Joseph R. Harper   +3 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Periodic Severe Angioedema without Exogenous Hormone Exposure

Iranian Journal of Allergy, Asthma and Immunology, 2021
Hereditary angioedema (HAE) is characterized by recurrent attacks of skin and mucosal swelling in any part of the body including the digestive and respiratory tract which generally improve spontaneously within 12-72 hours. The underlying mechanism in HAE
Mohammad Nabavi, Sima Bahrami, Saba Arshi, Afshin Rezaeifar, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Homan Tehrani   +7 more
doaj   +1 more source

A Novel C1-Esterase Inhibitor Oxygenator Coating Prevents FXII Activation in Human Blood

Biomolecules, 2020
The limited hemocompatibility of currently used oxygenator membranes prevents long-term use of artificial lungs in patients with lung failure. To improve hemocompatibility, we developed a novel covalent C1-esterase inhibitor (C1-INH) coating.
Katharina Gerling, Sabrina Ölschläger, Meltem Avci-Adali, Bernd Neumann, Ernst Schweizer, Christian Schlensak, Hans-Peter Wendel, Sandra Stoppelkamp   +7 more
doaj   +1 more source

Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs

Journal of Neuroinflammation, 2004
Background Oligodendrocytes, neurons, astrocytes, microglia, and endothelial cells are capable of synthesizing complement inhibitor proteins. Oligodendrocytes are vulnerable to complement attack, which is particularly observed in multiple sclerosis. This
McGeer Patrick L, Klegeris Andis, Hosokawa Masato   +2 more
doaj   +1 more source

DYNAMICS OF ACTIVITY OF SOME COMPONENTS OF COMPLEMENT IN TREATMENT OF ATOPIC DERMATITIS IN CHILDREN

Детские инфекции (Москва), 2015
The article describes immunoassay methods of determining the functional activity of the components C3 and C9 and C1 inhibitor for diagnostic and prognostic purposes in the treatment of patients.
S. S. Andina, A. M. Bichucher, N. V. Gora, L. V. Kozlov, O. V. Logunov, O. A. Bashkina, O. V. Rubalsky, A. V. Aleshkin   +7 more
doaj   +1 more source

Application of a dried blood spot based proteomic and genetic assay for diagnosing hereditary angioedema

Clinical and Translational Allergy, 2023
Background Hereditary angioedema (HAE) with C1‐inhibitor deficiency (C1‐INH‐HAE) is a rare disease caused by low level (type I) or dysfunction (type II) of the C1‐inhibitor protein with subsequent reduction of certain complement protein levels.
Marius‐Ionuţ Iuraşcu, Zsuzsanna Balla, Catarina Pereira, Noémi Andrási, Lilian Varga, Dorottya Csuka, Ágnes Szilágyi, Kornelia Tripolszki, Suliman Khan, Iuliana Susnea, Peter Bauer, Claudia Cozma, Henriette Farkas   +12 more
doaj   +1 more source

Paths reunited: initiation of the classical and lectin pathways of complement activation [PDF]

, 2010
Understanding the structural organisation and mode of action of the initiating complex of the classical pathway of complement activation (C1) has been a central goal in complement biology since its isolation almost 50 years ago.
Keeble, Anthony H., Mitchell, Daniel A., Schmid, Ralf, Schwaeble, Wilhelm J., Wallis, Russell   +4 more
core   +1 more source

Quantification of C1 esterase inhibitor in human serum by enzyme-linked immunosorbent assay: Correlation with turbidimetric immunoassay

Медицинская иммунология, 2023
C1 inhibitor of serine proteases (C1-INH) performs a regulatory function in the complement system and vascular permeability. Deficiency of C1-INH leads to various forms of angioedema, including hereditary angioedema (HAE).
N. P. Gorbunov, A. V. Zhakhov, I. N. Gorbunova, A. M. Milichkina, I. V. Drozd, A. V. Gubanova, E. M. Danilova, R. N. Kuznecova, T. V. Savin, A. G. Burtseva, N. V. Pigareva, A. M. Ischenko, Areg A. Totolian   +12 more
doaj   +1 more source

Amniotic fluid embolism pathophysiology suggests the new diagnostic armamentarium: β-tryptase and complement fractions C3-C4 are the indispensable working tools [PDF]

, 2015
Amniotic fluid embolism (AFE) is an uncommon obstetric condition involving pregnant women during labor or in the initial stages after delivery. Its incidence is estimated to be around 5.5 cases per 100,000 deliveries.
Busardo', FRANCESCO PAOLO, Fineschi, Vittorio, Frati, Paola, Zaami, Simona   +3 more
core   +2 more sources