Results 41 to 50 of about 65,236 (304)

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

Outcomes of long term treatments of type I hereditary angioedema in a Turkish family [PDF]

Anais Brasileiros de Dermatologia, 2017
: Background: Hereditary angioedema is a rare autosomal dominantly inherited immunodeficiency disorder characterized by potentially life-threatening angioedema attacks.
Gulsen Akoglu, Belgin Kesim, Gokhan Yildiz, Ahmet Metin   +3 more
doaj   +2 more sources

The Activation of JAK/STAT3 Signaling and the Complement System Modulate Inflammation in the Primary Human Dermal Fibroblasts of PXE Patients

Biomedicines, 2023
Previous studies revealed a link between inflammation and overactivation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling in syndromes associated with aging.
Christopher Lindenkamp, Ricarda Plümers, Michel R. Osterhage, Olivier M. Vanakker, Judith Van Wynsberghe, Cornelius Knabbe, Doris Hendig   +6 more
doaj   +1 more source

The correlation between inflammatory biomarkers and polygenic risk score in Alzheimer's Disease [PDF]

, 2017
Plasma biomarkers to aid the early diagnosis of Alzheimer’s disease (AD) or to monitor disease progression have long been sought and continue to be widely studied.
Escott-Price, Valentina, Jones, Lesley, Majounie, Elisa, Morgan, Angharad, Morgan, Bryan, O'Hagan, Caroline, Sims, Rebecca, Touchard, Samuel, Williams, Julie   +8 more
core   +1 more source

Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis

International Journal of Molecular Sciences, 2022
Autoantibodies against the complement component C1q (anti-C1q) are among the main biomarkers in lupus nephritis (LN) known to contribute to renal injury.
M. Radanova, V. Vasilev, G. Mihaylova, M. Kosturkova, U. Kishore, L. Roumenina   +5 more
semanticscholar   +1 more source

Acquisition of C1 inhibitor by Bordetella pertussis virulence associated gene 8 results in C2 and C4 consumption away from the bacterial surface.

PLoS Pathogens, 2017
Whooping cough, or pertussis, is a contagious disease of the respiratory tract that is re-emerging worldwide despite high vaccination coverage. The causative agent of this disease is the Gram-negative Bordetella pertussis. Knowledge on complement evasion
Elise S Hovingh, Bryan van den Broek, Betsy Kuipers, Elena Pinelli, Suzan H M Rooijakkers, Ilse Jongerius   +5 more
doaj   +1 more source

Angioedema hereditario en Medellín, Colombia: evaluación clínica y de la calidad de vida

Biomédica: revista del Instituto Nacional de Salud, 2015
Introducción. El angioedema hereditario es una inmunodeficiencia primaria de carácter autosómico dominante, debida a un déficit en la proteína inhibidora del factor C1 y caracterizada por episodios recurrentes de edema subcutáneo y de las mucosas.
María Dulfary Sánchez, Julián Cuervo, Deisi Rave, Gustavo Clemen, Juan José Yepes-Núñez, Blanca Ortiz-Reyes, Sara Sus, Ricardo Cardona   +7 more
doaj   +1 more source

Complement Component 1 Inhibitor (Cl-INH) Like Protein on Murine Spermatozoa: Anti-Cl-INH InhibitsIn VitroFertilization

Autoimmunity, 1998
We investigated if complement component 1 inhibitor-like (C1-INH-L) protein found on human spermatozoa exists on mouse spermatozoa and is relevant to reproduction. We used Western blot analysis and immunofluorescence assays to detect C1-INH on murine sperm and tested the effects of the antibodies to C1-INH and albumin (negative control) on in vitro ...
Huamei Zhang, Haixiang Jiang, W. E. Roudebush, Subbi Pillai, M. Waheba   +4 more
openaire   +3 more sources

Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. [PDF]

, 2013
BackgroundThe aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression.
Boutros, Paul C, Chamankhah, Mahmood, Eftekharpour, Eftekhar, Fehlings, Michael G, Karimi-Abdolrezaee, Soheila, San-Marina, Serban   +5 more
core   +3 more sources

Molecular basis for B. pertussis interference with complement, coagulation, fibrinolytic and contact activation systems: The cryo-EM structure of the Vag8-C1 inhibitor complex

bioRxiv, 2020
Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, C1-inhibitor (C1-INH) is a key regulator (inhibitor) of serine proteases of all the above ...
A. Dhillon, J. Deme, E. Furlong, D. Roem, I. Jongerius, Steven Johnson, S. Lea   +6 more
semanticscholar   +1 more source