Results 111 to 120 of about 729,206 (315)

Anti-SARS-Cov-2 S-RBD IgG Formed after BNT162b2 Vaccination Can Bind C1q and Activate Complement

Journal of Immunology Research, 2022
Background. The ability of vaccine-induced antibodies to bind C1q could affect pathogen neutralization. In this study, we investigated C1q binding and subsequent complement activation by anti-spike (S) protein receptor-binding domain (RBD) specific ...
Anas H. A. Abu-Humaidan, Fatima M. Ahmad, Dima Awajan, Raba’a F. Jarrar, Nader Alaridah   +4 more
doaj   +1 more source

Antimicrobial peptides and complement in neonatal hypoxia-ischemia induced brain damage [PDF]

, 2015
Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1-5/1000 live births worldwide and is associated with the development of neurological deficits ...
Hristova, M, Rocha-Ferreira, E
core   +1 more source

Interaction between complement subcomponent C1q and bacterial lipopolysaccharides [PDF]

Biochemical Journal, 1989
The heptose-less mutant of Escherichia coli, D31m4, bound complement subcomponent C1q and its collagen-like fragments (C1qCLF) with Ka values of 1.4 x 10(8) and 2.0 x 10(8) M-1 respectively. This binding was suppressed by chemical modification of C1q and C1qCLF using diethyl pyrocarbonate (DEPC).
R. H. Wade, S. Chesne, Abdellah Zohair, Maurice G. Colomb   +3 more
openaire   +3 more sources

Parkinson disease is a TH17 dominant autoimmune disorder against accumulated alpha-synuclein [PDF]

arXiv, 2013
Parkinson disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson disease is still unknown, so it is called idiopathic Parkinsonism.
arxiv  

Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury

Glia, EarlyView.
Astrocytes play an important role in glaucoma. These cells express Cx43, which can form gap junctions and hemichannels. This study shows that Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation. ABSTRACT Astrocytes in the retina and optic nerve head play an important role in the pathogenesis of ...
Khulan Batsuuri, Abduqodir H. Toychiev, Suresh Viswanathan, Stefanie G. Wohl, Miduturu Srinivas   +4 more
wiley   +1 more source

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration

Molecular Neurodegeneration, 2018
Background The role of the alternative complement pathway and its mediation by retinal microglia and macrophages, is well-established in the pathogenesis of Age-Related Macular Degeneration (AMD).
Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan, Riemke Aggio-Bruce, Jan Provis, Riccardo Natoli   +7 more
doaj   +1 more source

Decidability of Existence and Construction of a Complement of a given Function [PDF]

arXiv, 2011
This article defines a complement of a function and conditions for existence of such a complement function and presents few algorithms to construct a complement.
arxiv  

A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system [PDF]

, 2008
The M protein of Streptococcus equi subsp. equi known as fibrinogen-binding protein (FgBP) is a cell wall-associated protein with antiphagocytic activity that binds IgG. Recombinant versions of the seven equine IgG subclasses were used to investigate the
Abi-Rached, Berge, Boschwitz, Boschwitz, Bruggemann, Burton, Burton, Carlsson, Deisenhofer, DeLano, Flock, Flock, Galan, Galan, Galan, Ghetie, Harrington, Herr, Jonsson, Lancet, Lewis, Lindmark, Meehan, Meehan, Meehan, Meehan, Meehan, Morton, Newton, Nitsche-Schmitz, Pleass, Pleass, Ramsland, Recht, Sauer-Eriksson, Sheoran, Sheoran, Taylor, Timoney, Timoney, Timoney, van Loghem, Wagner, Wagner, Wagner, Waller, Wines, Wines, Wolbink, Åkerström   +49 more
core   +3 more sources

Circulating Complement-C1q TNF-Related Protein 1 Levels Are Increased in Patients with Type 2 Diabetes and Are Associated with Insulin Sensitivity in Chinese Subjects

PLoS ONE, 2014
Background Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored.
Xuebo Pan, T. Lu, Fan Wu, Leigang Jin, Yi Zhang, Lihua Shi, Xiaokun Li, Zhuofeng Lin   +7 more
semanticscholar   +1 more source

Microglial IKKβ Alters Central and Peripheral Immune Activity at Distinct Time Points After Spinal Cord Injury

Glia, EarlyView.
Microglial NF‐κB signaling increases M1‐like spinal microglia over time after spinal cord injury. Microglial NF‐κB signaling broadly affects gene expression in spinal cord. Microglial NF‐κB signaling modulates splenocytes acutely after spinal cord injury.
Micaela L. O'Reilly, Mariah J. Wulf, Theresa M. Connors, Ying Jin, Frank Bearoff, Julien Bouyer, Sandhya Kortagere, John R. Bethea, Veronica J. Tom   +8 more
wiley   +1 more source