Results 131 to 140 of about 42,931 (245)

Binding of complement subcomponent C1q to Streptococcus pyogenes: evidence for interactions with the M5 and FcRA76 proteins [PDF]

, 2006
I. V. Koroleva, Anders G. Sjöholm, Claes Schalén   +2 more
openalex   +1 more source

Complement and non-complement activating functions of C1q: A prototypical innate immune molecule

Innate Immunity, 2011
C1q is a versatile innate immune molecule that serves as the initiation subcomponent of the classical complement pathway. In addition, it is also a potent pattern recognition molecule, the versatility of which has fuelled its functional flexibility. C1q recognises an array of self, non-self and altered-self ligands.
Annapurna, Nayak, Lina, Pednekar, Kenneth B M, Reid, Uday, Kishore   +3 more
openaire   +2 more sources

Circulating Metabolites Treat Human TMJ‐OA by Eliminating Senescent Chondrocytes via the C1QBP/C1q/p14ARF Axis

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT Temporomandibular joint osteoarthritis (TMJ‐OA) is a progressive degenerative disorder, for which therapeutic interventions remain limited. The disruption of metabolic homeostasis plays a critical role in the pathogenesis and advancement of TMJ‐OA.
Bowen Meng, Xin Li, Benyi Yang, Yan Qu, Yifan He, Chaoran Fu, Zhe An, Antong Wu, Yuzhuo Hei, Rong Zhang, Wenyi Cai, Lingyunbo Kong, Rui Li, Meng Hao, Zeyuan Cao, Xueli Mao, Janak Lal Pathak, Yang Cao, Songtao Shi, Qingbin Zhang   +19 more
wiley   +1 more source

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice [PDF]

, 2015
Emily M. Rocha, Gaynor A. Smith, Eric Park, Hongmei Cao, Anne-Renee Graham, Eilish Brown, Jesse R. McLean, Melissa A. Hayes, Jonathan A. Beagan, Sarah C. Izen, Eduardo Pérez-Torres, Penelope J. Hallett, Ole Isacson   +12 more
openalex   +1 more source

RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer [PDF]

, 2015
Thatchawan Thanasupawat, Aleksandra Głogowska, Maxwell Burg, G. William Wong, Cuong Hoang‐Vu, Sabine Hombach‐Klonisch, Thomas Klonisch   +6 more
openalex   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Antibody-independent binding of complement component C1q by Legionella pneumophila [PDF]

, 1995
C S Mintz, Patricia I. Arnold, William Johnson, D. R. Schultz   +3 more
openalex   +1 more source

Galectin-3 – A novel ligand of complement protein C1q

International Journal of Biological Macromolecules
In the present study we report a novel interaction of human C1q, a primary activator of the Complement system, with human Galectin-3 (Gal-3). We investigated the potential recognition between C1q and Gal-3 on a solid hydrophobic surface by ELISA, by fluorescence spectroscopy, molecular docking and molecular dynamics (MD).
Gabriela Radulova, Alexandra Kapogianni, Ginka Cholakova, Stoyan Iliev, Anela Ivanova, Vanya Bogoeva, Ivanka Tsacheva   +6 more
openaire   +2 more sources

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Stem Cell Therapy for Inflammatory Diseases: Progress, Challenges, and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Stem cells offer multifaceted therapeutic approaches for inflammatory diseases, each exhibiting distinct therapeutic properties. Hematopoietic stem cells, primarily through hematopoietic stem cell transplantation (HSCT), can effectively remodel the immune environment, showing particular promise in treating genetically linked cases.
Chen Wu, Zhi‐Ping Jin, Shu‐Qiang Weng, Ji‐Min Zhu, Ling Dong   +4 more
wiley   +1 more source