Results 141 to 150 of about 41,476 (260)

A Surface Plasmon Resonance‐Based Integrated Assay for Quantification and Glycosylation Characterization of Monoclonal Antibodies in Crude Heterogeneous Samples

Biotechnology and Bioengineering, Volume 122, Issue 10, Page 2724-2738, October 2025.
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer, Catherine Forest‐Nault, Julie Guimond, Simon Joubert, Olivier Henry, Yves Durocher, Gregory De Crescenzo, Jimmy Gaudreault   +7 more
wiley   +1 more source

Complement-Coagulation Cross-talk: Factor H-mediated regulation of the Complement Classical Pathway activation by fibrin clots

Frontiers in Immunology
The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory protein of the complement alternative pathway. However,
Yu-Hoi Kang, Yu-Hoi Kang, Praveen M. Varghese, Ahmad Al Aiyan, Kirsten Pondman, Uday Kishore, Uday Kishore, Robert B. Sim   +7 more
doaj   +1 more source

Complement C1q and von Willebrand factor interaction in atherosclerosis of human carotid artery. [PDF]

Front Immunol, 2023
Schulz K, Donat C, Punjabi M, Glatz K, Kaufmann B, Trendelenburg M.   +5 more
europepmc   +1 more source

Anti-C1q autoantibodies do not correlate with the occurrence or severity of experimental lupus nephritis [PDF]

, 2017
Background. In systemic lupus erythematosus patients, a strong association between the occurrence of antibodies against complement C1q (anti-C1q) and lupus nephritis can be observed.
Bigler, Cornelia, Danner, Doris, Hopfer, Helmut, Mihatsch, Michael J., Schaller, Monica, Trendelenburg, Marten   +5 more
core  

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

Cancer Communications, Volume 45, Issue 10, Page 1203-1228, October 2025.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan, Jinsong Xu, Zhanqiao Zhang, Yating Hu, Yongsheng Li, Junying Qian, Yunyan Ling, Dehua Wu, Haijun Deng, Guoxin Li, Zhiyong Shen, Yuan Fang   +11 more
wiley   +1 more source

Neurodevelopmental Impact of Prenatal Stress: A Proteomic Analysis of Myelination Disruptions in the Avian Embryo

Developmental Neurobiology, Volume 85, Issue 4, October 2025.
ABSTRACT Prenatal stress, mediated by elevated glucocorticoid (GC) levels, is a relevant modulator of fetal brain development and a known risk factor for neurodevelopmental disorders. Using the avian embryo as a vertebrate model, we injected corticosterone into the yolk on embryonic day 6 (E6) and assessed neurodevelopmental outcomes at day 14 (E14 ...
Bela Gaertner, Gabriela Morosan‐Puopolo, Beate Brand‐Saberi, Charmaine Schücke, Darius Saberi, Katharina Klöster, Simon Faissner, Katrin Marcus, Morris Gellisch, Britta Eggers   +9 more
wiley   +1 more source

Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae [PDF]

, 2007
The physiological functions of the acute phase protein serum amyloid P (SAP) component are not well defined, although they are likely to be important, as no natural state of SAP deficiency has been reported.
Botto, M., Bottoms, S.E., Brown, J.S., Yuste, J.   +3 more
core  

Pathways to Progressive Disability in Multiple Sclerosis: The Role of Glial Cells in Chronic CNS Inflammation

Glia, Volume 73, Issue 10, Page 1928-1950, October 2025.
Main Points Multiple sclerosis involves chronic CNS inflammation and neurodegeneration. This review highlights glial cells as key drivers in progressive MS, focusing on lesion pathology, molecular dysfunction, and human‐relevant model systems. ABSTRACT Multiple sclerosis (MS) is the most common non‐infectious inflammatory CNS disease, characterized by ...
Volker Siffrin
wiley   +1 more source

Formation of complement subcomponent C1q-immunoglobulin G complex. Thermodynamic and chemical-modification studies [PDF]

, 1982
E. J. Emanuel, A. D. Brampton, Dennis R. Burton, Raymond A. Dwek   +3 more
openalex   +1 more source

Engineering Efferocytosis for Bone Regeneration

Macromolecular Bioscience, Volume 25, Issue 10, October 2025.
The repair of bone tissue in acute and chronic injuries is a significant long‐standing clinical challenge. Biomaterials‐based interventions are well‐positioned to interrogate mechanisms of efferocytosis due to their ability to provide support and guide cellular activity.
Jacob Miszuk, Linna Zhong, Hongli Sun
wiley   +1 more source